| Summary: | Purpose Couinaud’s liver segment classification has been widely adopted for liver surgery planning, yet its rigid anatomical boundaries often fail to align precisely with individual patient anatomy. This study proposes a novel patient-specific liver segmentation method based on detailed classification of hepatic and portal veins to improve anatomical adherence and clinical relevance.Methods Our proposed method involves two key stages: (1) surgeons annotate vascular endpoints on 3D models of hepatic and portal veins, from which vessel centerlines are computed; and (2) liver segments are calculated by assigning voxel labels based on proximity to these vascular centerlines. The accuracy and clinical applicability of our Hepatic and Portal Vein-based Classification (HPVC) were compared with conventional Plane-Based Classification (PBC), Portal Vein-Based Classification (PVC), and an automated deep learning method (nnU-Net) using volumetric measurements, Dice similarity scores, and expert evaluations.Results HPVC demonstrated superior anatomical conformity compared to traditional methods, especially in complex segments like 5 and 8, providing segmentations more reflective of actual vascular territories. Volumetric analysis revealed significant discrepancies among the methods, particularly with nnU-Net generally producing larger segment volumes. HPVC consistently achieved higher surgeon-rated scores in patient-specific anatomical adherence, perfusion region assessment, and accuracy in surgical planning compared to PBC, PVC, and nnU-Net.Conclusion The presented HPVC method offers substantial improvements in liver segmentation precision, especially relevant for surgical planning in anatomically complex cases. Its integration into clinical workflows via the open-source platform 3D Slicer significantly enhances its accessibility and usability.
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