A Model In Vitro Study Using Hypericin: Tumor-Versus Necrosis-Targeting Property and Possible Mechanisms

Hypericin (Hyp) had been explored as a tumor-seeking agent for years; however, more recent studies showed its necrosis-avidity rather than cancer-seeking property. To further look into this discrepancy, we conducted an in vitro study on Hyp retention in vital and dead cancerous HepG2 and normal LO2...

Full description

Bibliographic Details
Published in:	Biology
Main Authors:	Yue Li, Shuncong Wang, Yuanyu Zhao, Hexige Saiyin, Xiaoyan He, Juanzhi Zhao, Ling Li, Ali Talebi, Gang Huang, Yicheng Ni
Format:	Article
Language:	English
Published:	MDPI AG 2020-01-01
Subjects:	hypericin necrosis-avidity liver cancer fluorescence confocal microscopy and mechanism
Online Access:	https://www.mdpi.com/2079-7737/9/1/13

Similar Items

Detection of a Water-Soluble Hypericin Formulation in Glioblastoma Tissue with Fluorescence Lifetime and Intensity Using a Dual-Tap CMOS Camera System
by: Mario Mischkulnig, et al.
Published: (2024-10-01)

Effect of Hypericin-Mediated Photodynamic Therapy on the Secretion of Soluble TNF Receptors by Oral Cancer Cells
by: Marcin Olek, et al.
Published: (2023-04-01)

Bilayer Dissolving Microneedles Incorporating Hypericin-Loaded Nanocapsules For Improved Localised Photodynamic Therapy
by: Heba M. Abd-El-Azim, et al.
Published: (2019-04-01)

Photodynamic therapy – hypericin tetraether liposome conjugates and their antitumor and antiangiogenic activity
by: Nikola Plenagl, et al.
Published: (2019-01-01)

Inhibitory Activity and Mechanism Investigation of Hypericin as a Novel <i>α</i>-Glucosidase Inhibitor
by: Qi Dong, et al.
Published: (2021-07-01)

Immunomodulatory Effect of Hypericin-Mediated Photodynamic Therapy on Oral Cancer Cells
by: Marcin Olek, et al.
Published: (2023-12-01)

On the Mechanism of Action of Anti-Inflammatory Activity of Hypericin: An In Silico Study Pointing to the Relevance of Janus Kinases Inhibition
by: Luca Dellafiora, et al.
Published: (2018-11-01)

The Effects of Photosensitizing Dyes Fagopyrin and Hypericin on Planktonic Growth and Multicellular Life in Budding Yeast
by: Oksana Sytar, et al.
Published: (2021-08-01)

Variation in quantitative yield and hypericin content of St. John’s wort., Hypericum perforatum L.
by: H Naghdi Badi, et al.
Published: (2004-09-01)

Transplacental passage of hyperforin, hypericin, and valerenic acid
by: Deborah Spiess, et al.
Published: (2023-03-01)

Hypericin Inhibit Alpha-Coronavirus Replication by Targeting 3CL Protease
by: Yue Zhang, et al.
Published: (2021-09-01)

Novel Hypericin-loaded nanoparticles as a new drug delivery system ameliorate olanzapine-induced early renal injury and oxidative stress: In vitro and in vivo approaches
by: Abeer M. Abd El-Hameed, et al.
Published: (2025-05-01)

Hypericin regulates the intestinal microbiota, promotes intestinal development, and improves the apparent digestible rates of nutrients in broilers
by: Yanzhen Jiang, et al.
Published: (2025-10-01)

Isolation and Determination of Hypericins from Different Parts of Hypericum triquetrifolium Turra Grown in Khozestan by UV/Visible Spectrophotometry
by: Nasrin Aghel, et al.
Published: (2012-07-01)

Cytotoxic and Immunomodulatory Effects of Hypericin as a Photosensitizer in Photodynamic Therapy Used on Skin Cell Cultures
by: Magdalena Krupka-Olek, et al.
Published: (2024-05-01)

Hypericin-Mediated Photodynamic Therapy for Head and Neck Cancers: A Systematic Review
by: Jakub Fiegler-Rudol, et al.
Published: (2025-01-01)

Hypericin Nanoparticles-Associated Photodynamic Therapy Modulates the Biological Behavior of Hepatocellular Carcinoma by SERPINE1
by: Yan X, et al.
Published: (2025-03-01)

Biophysical Characterization and Anticancer Activities of Photosensitive Phytoanthraquinones Represented by Hypericin and Its Model Compounds
by: Valéria Verebová, et al.
Published: (2020-12-01)

Ultrasound Triggers Hypericin Activation Leading to Multifaceted Anticancer Activity
by: Federica Foglietta, et al.
Published: (2022-05-01)

Investigation of the effect of hyperforin and hypericin on inflammatory response in RAW 264.7 macrophages
by: Mehmet Berköz, et al.
Published: (2018-04-01)

Hypericin Ameliorates Depression-like Behaviors via Neurotrophin Signaling Pathway Mediating m6A Epitranscriptome Modification
by: Chunguang Lei, et al.
Published: (2023-05-01)

Necrosis binding of Ac-Lys0(IRDye800CW)-Tyr3-octreotate: a consequence from cyanine-labeling of small molecules
by: Marcus C. M. Stroet, et al.
Published: (2021-05-01)

A Double Payload Complex between Hypericin and All-<em>trans</em> Retinoic Acid in the β-Lactoglobulin Protein
by: Beatriz Rodríguez-Amigo, et al.
Published: (2022-02-01)

MALDI-HRMS Imaging Maps the Localization of Skyrin, the Precursor of Hypericin, and Pathway Intermediates in Leaves of <i>Hypericum</i> Species
by: Bharadwaj Revuru, et al.
Published: (2020-08-01)

Green synthesis and in vitro photodynamic efficacy of hypericin: Cytotoxicity assessment on MCF-7 breast cancer cells
by: Monosha Priyadarshini, et al.
Published: (2024-12-01)

Conjugation of Hypericin to Gold Nanoparticles for Enhancement of Photodynamic Therapy in MCF-7 Breast Cancer Cells
by: Dimakatso Mokoena, et al.
Published: (2022-10-01)

Light-Induced Photoactivation of Hypericin Inhibits Cellular Growth in Pituitary Adenoma Cell Line AtT20/D16v-F2 (Hypericin Inhibits Cellular Growth of AtT20/D16v-F2)
by: Martina Mareková, et al.
Published: (2001-01-01)

Comparison of hypericin content, antioxidant, antimicrobial and cytotoxic activities of Hypericum perforatum L. from three geographic regions of Iran
by: M Akhbari, et al.
Published: (2017-03-01)

Enhanced hypericin production in Hypericum perforatum and Hypericum pruinatum in response to inoculation with two fungal pathogens
by: Cüneyt Çirak, et al.
Published: (2005-09-01)

Hypericin-Mediated Photodynamic Inactivation Against the Plant Pathogen <i>Clavibacter michiganensis</i>: Preventative Seed Decontamination Enhanced by Potassium Iodide
by: Linda Jernej, et al.
Published: (2025-10-01)

Evolutionary Aspects of Hypericin Productivity and Endogenous Phytohormone Pools Evidenced in <i>Hypericum</i> Species In Vitro Culture Model
by: Kalina Danova, et al.
Published: (2022-10-01)

Selection of Unique Molecules for Cancer Treatment by Distance-Based Method: Hypericin Effect on Respiratory Chain
by: Denis Horvath, et al.
Published: (2021-06-01)

Imaging quality enhancement for high numerical aperture confocal scanning fluorescence microscopy by using two beams
by: Le Van Nhu, et al.
Published: (2023-02-01)

Physiological and Transcriptomic Analysis Provide Insight into Low Temperature Enhancing Hypericin Biosynthesis in <i>Hypericum perforatum</i>
by: Hongyan Su, et al.
Published: (2021-04-01)

Compatibility study of topical 0.25% hypericin (HyBryteTM) application in subjects with mycosis fungoides: Results of the HPN‐CTCL‐02 study
by: Carolina V. Alexander‐Savino, et al.
Published: (2024-09-01)

Hypericin Suppresses SARS-CoV-2 Replication and Synergizes with Antivirals via Dual Targeting of RdRp and 3CLpro
by: Helena da Silva Souza, et al.
Published: (2025-04-01)

Hypericin and Pheophorbide a Mediated Photodynamic Therapy Fighting MRSA Wound Infections: A Translational Study from In Vitro to In Vivo
by: Ben Chung Lap Chan, et al.
Published: (2021-09-01)

Hypericin Enhances Paclitaxel-Induced B16-F10 Cell Apoptosis by Activating a Cytochrome c Release–Dependent Pathway
by: Liyun Sun, et al.
Published: (2021-08-01)

Establishment of C-33A cervical carcinoma spheroids on Japanese quail CAM: relevance in assessment of photodiagnosis and photodynamic therapy mediated by hypericin
by: Mariana Máčajová, et al.
Published: (2025-10-01)

Selective photodynamic effects on cervical adenocarcinoma cells provided by F127 Pluronic®-based micelles modulating hypericin delivery
by: Kayane Harumi Mashiba, et al.
Published: (2023-05-01)