Molecular Mechanism of Ochratoxin A Transport in the Kidney
The mycotoxin, ochratoxin A (OTA), is thought to be responsible for Balkan endemic nephropathy. OTA accumulates in several tissues, especially in the kidneys and liver. The excretion of OTA into urine is thought to be mainly by tubular secretion, presumably via the organic anion transport system. Re...
| Published in: | Toxins |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2010-06-01
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| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6651/2/6/1381/ |
| _version_ | 1852702064333815808 |
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| author | Naohiko Anzai Promsuk Jutabha Hitoshi Endou |
| author_facet | Naohiko Anzai Promsuk Jutabha Hitoshi Endou |
| author_sort | Naohiko Anzai |
| collection | DOAJ |
| container_title | Toxins |
| description | The mycotoxin, ochratoxin A (OTA), is thought to be responsible for Balkan endemic nephropathy. OTA accumulates in several tissues, especially in the kidneys and liver. The excretion of OTA into urine is thought to be mainly by tubular secretion, presumably via the organic anion transport system. Recently, several families of multispecific organic anion transporters have been identified: organic anion transporters (OATs), organic anion-transporting polypeptides (OATPs), oligopeptide transporters (PEPTs), and ATP-binding cassette (ABC) transporters, such as MRP2 and BCRP. These renal transporters mediate the transmembrane transport of OTA and play a pivotal role in the development of OTA-induced nephrotoxicity. |
| format | Article |
| id | doaj-art-8bb8bbcb67a04b8e8aae698abdd6dbe3 |
| institution | Directory of Open Access Journals |
| issn | 2072-6651 |
| language | English |
| publishDate | 2010-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-8bb8bbcb67a04b8e8aae698abdd6dbe32025-08-19T21:20:07ZengMDPI AGToxins2072-66512010-06-01261381139810.3390/toxins2061381Molecular Mechanism of Ochratoxin A Transport in the KidneyNaohiko AnzaiPromsuk JutabhaHitoshi EndouThe mycotoxin, ochratoxin A (OTA), is thought to be responsible for Balkan endemic nephropathy. OTA accumulates in several tissues, especially in the kidneys and liver. The excretion of OTA into urine is thought to be mainly by tubular secretion, presumably via the organic anion transport system. Recently, several families of multispecific organic anion transporters have been identified: organic anion transporters (OATs), organic anion-transporting polypeptides (OATPs), oligopeptide transporters (PEPTs), and ATP-binding cassette (ABC) transporters, such as MRP2 and BCRP. These renal transporters mediate the transmembrane transport of OTA and play a pivotal role in the development of OTA-induced nephrotoxicity.http://www.mdpi.com/2072-6651/2/6/1381/ochratoxin Amycotoxinorganic anion transporterkidneynephrotoxicity |
| spellingShingle | Naohiko Anzai Promsuk Jutabha Hitoshi Endou Molecular Mechanism of Ochratoxin A Transport in the Kidney ochratoxin A mycotoxin organic anion transporter kidney nephrotoxicity |
| title | Molecular Mechanism of Ochratoxin A Transport in the Kidney |
| title_full | Molecular Mechanism of Ochratoxin A Transport in the Kidney |
| title_fullStr | Molecular Mechanism of Ochratoxin A Transport in the Kidney |
| title_full_unstemmed | Molecular Mechanism of Ochratoxin A Transport in the Kidney |
| title_short | Molecular Mechanism of Ochratoxin A Transport in the Kidney |
| title_sort | molecular mechanism of ochratoxin a transport in the kidney |
| topic | ochratoxin A mycotoxin organic anion transporter kidney nephrotoxicity |
| url | http://www.mdpi.com/2072-6651/2/6/1381/ |
| work_keys_str_mv | AT naohikoanzai molecularmechanismofochratoxinatransportinthekidney AT promsukjutabha molecularmechanismofochratoxinatransportinthekidney AT hitoshiendou molecularmechanismofochratoxinatransportinthekidney |