EGFR tyrosine kinase inhibitor: design, synthesis, characterization, biological evaluation, and molecular docking of novel 1,3,4-oxadiazole, thio-methyl, and 1,2,3-triazole hybrids

Abstract Concerning the structural analysis and optimization of various potential EGFR inhibitors. A series of heterocyclic compounds incorporating pyridine, 1,3,4-oxadiazole, thio-methyl, and 1,2,3-triazole were successfully synthesized via a click reaction 12–21, resulting in high yields. The synt...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Journal of Saudi Chemical Society
المؤلفون الرئيسيون:	Asma Khalaf Alshamari, Aljazi Abdullah AlRashidi, Faiza I. A. Abdella, Hissah Khashman Alshammari, Mona Zaheed Alshammari, Nuha Othman S. Alsaif, Tamer El Malah
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Springer 2025-07-01
الموضوعات:	EGFR Cancer 1,3,4-oxadiazole 1,2,3-triazole Apoptosis Cell cycle arrest
الوصول للمادة أونلاين:	https://doi.org/10.1007/s44442-025-00004-2

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