| الملخص: | Chemokines, also known as chemotactic cytokines, stimulate the migration of immune cells. These molecules play a key role in the pathogenesis of inflammation leading to atherosclerosis, neurodegenerative disorders, rheumatoid arthritis, insulin-resistant diabetes, and cancer. Moreover, they take part in inflammatory bowel disease (IBD). The main objective of our research was to determine the activity of methyl-derivatives of flavanone, namely, 2′-methylflavanone (<b>5B</b>), 3′-methylflavanone (<b>6B</b>), 4′-methylflavanone (<b>7B</b>), and 6-methylflavanone (<b>8B</b>), on the releasing of selected cytokines by RAW264.7 macrophages activated by LPS. We determined the concentration of chemokines belonging to the CC chemokine family, namely, MCP-1, MIP-1β, RANTES, and eotaxin, using the Bio-Plex Magnetic Luminex Assay and the Bio-PlexTM 200 System. Among the tested compounds, only <b>5B</b> and <b>6B</b> had the strongest effect on inhibiting the examined chemokines’ release by macrophages. Therefore, <b>5B</b> and <b>6B</b> appear to be potentially useful in the prevention of diseases associated with the inflammatory process.
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