Design principles of a microtubule polymerase

Stu2/XMAP215 microtubule polymerases use multiple tubulin-binding TOG domains and a lattice-binding basic region to processively promote faster elongation. How the domain composition and organization of these proteins dictate polymerase activity, end localization, and processivity is unknown. We sho...

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Bibliographic Details
Published in:	eLife
Main Authors:	Elisabeth A Geyer, Matthew P Miller, Chad A Brautigam, Sue Biggins, Luke M Rice
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2018-06-01
Subjects:	Microtubule dynamics Microtubule polymerase In vitro reconstitution
Online Access:	https://elifesciences.org/articles/34574

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