Calcitriol Attenuates Doxorubicin-Induced Cardiac Dysfunction and Inhibits Endothelial-to-Mesenchymal Transition in Mice

Doxorubicin (Dox) is an effective anti-neoplasm drug, but its cardiac toxicity limits its clinical use. Endothelial-to-mesenchymal transition (EndMT) has been found to be involved in the process of heart failure. It is unclear whether EndMT contributes to Dox-induced cardiomyopathy (DoIC). Calcitrio...

Full description

Bibliographic Details
Published in:	Cells
Main Authors:	Tzu-Hsien Tsai, Cheng-Jei Lin, Chi-Ling Hang, Wei-Yu Chen
Format:	Article
Language:	English
Published:	MDPI AG 2019-08-01
Subjects:	endothelial-to-mesenchymal transition doxorubin cardiac fibrosis calcitriol
Online Access:	https://www.mdpi.com/2073-4409/8/8/865

Similar Items

Calcitriol modulates the effects of bone marrow-derived mesenchymal stem cells on macrophage functions
by: Bahman Mansouri Motlagh, et al.
Published: (2015-07-01)

Anti-inflammatory effects of calcitriol-treated mesenchymal stem cells on experimental ulcerative colitis
by: Hossein Abdi, et al.
Published: (2021-12-01)

Integrated Synthesis of Calcitriol and 26,27-Hexadeutero Calcitriol
by: Fei Tang, et al.
Published: (2024-06-01)

Liraglutide Inhibits Endothelial-to-Mesenchymal Transition and Attenuates Neointima Formation after Endovascular Injury in Streptozotocin-Induced Diabetic Mice
by: Tzu-Hsien Tsai, et al.
Published: (2019-06-01)

Ginsenoside Rg3 attenuates pulmonary fibrosis by inhibiting endothelial to mesenchymal transition
by: Eunsik Yun, et al.
Published: (2023-12-01)

Secondary Prevention of Diabetes Type 1 with Oral Calcitriol and Analogs, the PRECAL Study
by: Dimitrios T. Papadimitriou, et al.
Published: (2023-05-01)

Calcitriol inhibits COX-1 and COX-2 expressions of renal vasculature in hypertension: Reactive oxygen species involved?
by: Zizheng Suo, et al.
Published: (2021-01-01)

Valproic Acid Induces Endothelial-to-Mesenchymal Transition-Like Phenotypic Switching
by: Shamini Murugavel, et al.
Published: (2018-07-01)

Regulation of Inflammation-Mediated Endothelial to Mesenchymal Transition with Echinochrome a for Improving Myocardial Dysfunction
by: Byeong-Wook Song, et al.
Published: (2022-11-01)

Calcitriol supplementation attenuates cisplatin-induced behavioral and cognitive impairments through up-regulation of BDNF in male rats
by: Maryam abdollahzadeh, et al.
Published: (2022-04-01)

Efecto de dosis suprafisiológicas de calcitriol sobre la expresión proteica de células de músculo liso vascular
by: Carrillo López N, et al.
Published: (2017-12-01)

Endothelial Cell-Specific Molecule 1 Promotes Endothelial to Mesenchymal Transition in Renal Fibrosis
by: Tung-Wei Hung, et al.
Published: (2020-08-01)

Irisin ameliorates doxorubicin-induced cardiac perivascular fibrosis through inhibiting endothelial-to-mesenchymal transition by regulating ROS accumulation and autophagy disorder in endothelial cells
by: Jian-an Pan, et al.
Published: (2021-10-01)

The Evaluation of Efficacy of Calcitriol on Bone Mineral Density, Pain and Quality of Life in Postmenopausal Osteoporotic Patients With or Without Depression
by: Halil Koyuncu, et al.
Published: (2003-12-01)

Calcitriol Concentration in the Early Phase of Myocardial Infarction and Its Relation to Left Ventricular Ejection Fraction
by: Szymon Olędzki, et al.
Published: (2024-12-01)

Respon Sistem Homeostasis Kalsium Tikus Ovariektomi yang Mengkonsumsi Kombinasi Calcitriol dengan Raloxifene
by: Hartiningsih Hartiningsih, et al.
Published: (2017-02-01)

Suplemen Calcitriol Dosis Tinggi Mencegah Osteoporosis dan Memicu Urolitiasis pada Tikus Ovariektomi
by: hartiningsih hartiningsih, et al.
Published: (2021-09-01)

Cytotoxic effects of calcitriol on osteosarcoma cells
by: Hümeyra Çelik, et al.
Published: (2022-10-01)

Peroxygenase-Catalyzed Selective Synthesis of Calcitriol Starting from Alfacalcidol
by: Yuanying Li, et al.
Published: (2022-05-01)

Meta-analysis of cinacalcet plus calcitriol for the treatment of secondary hyperparathyroidism in hemodialysis patients
by: Feng Hui-ling, et al.
Published: (2022-06-01)

Comprehension of Calcitriol Levels in Pregnant Women With Latent Tuberculosis and Immune Function in their Newborns
by: Meirina F, et al.
Published: (2024-04-01)

Role of MCPIP1 in the Endothelial-Mesenchymal Transition Induced by Silica
by: Jie Chao, et al.
Published: (2016-11-01)

Research advances of endothelial-mesenchymal transition during peritoneal dialysis-related peritoneal fibrosis
by: Liao Meng, et al.
Published: (2021-01-01)

Endothelial to Mesenchymal Transition in Pulmonary Vascular Diseases
by: Eunsik Yun, et al.
Published: (2020-12-01)

THE EFFECTIVENESS OF THE COMBINATIONS OF CALCITRIOL AND ETHYNIL ETHYL ESTRADIOL TO DECREASE OSTEOPOROSIS AND ENDOMETRIAL CANCER RISKS IN OVARIECTOMIZED RATS
by: Hartiningsih Hartiningsih, et al.
Published: (2017-08-01)

The Investigation of the Effects of Calcitriol on Human Ovarian Carcinoma Cells
by: 10.46332/aemj.1228216, et al.
Published: (2024-04-01)

Calcitriol Protects against Acetaminophen-Induced Hepatotoxicity in Mice
by: Supachaya Sriphoosanaphan, et al.
Published: (2023-05-01)

Steroid responsive idiopathic calcitriol induced hypercalcemia: a case report and review of the literature
by: Omar El Fadel, et al.
Published: (2023-06-01)

Orthotopic tumorgrafts in nude mice as a model to evaluate calcitriol effects in breast cancer
by: V. C. N. Fonseca-Filho, et al.
Published: (2017-05-01)

Detecting rickets in premature infants and treating them with calcitriol: Experience from two cases
by: Hung-Yi Chen, et al.
Published: (2012-08-01)

The effects of calcitriol on microalbuminuria in patients with type 2 diabetes mellitus; a double-blind randomized clinical trial
by: Maryam Askari, et al.
Published: (2024-05-01)

Pathophysiology in Brain Arteriovenous Malformations: Focus on Endothelial Dysfunctions and Endothelial-to-Mesenchymal Transition
by: Jae Yeong Jeong, et al.
Published: (2024-08-01)

Reparative effects of paricalcitol and calcitriol in patients with cardiorenal syndrome and chronic allograft nephropathy
by: A. N. Kharlamov, et al.
Published: (1970-01-01)

Observation of low dosage of cinacalcet combined with calcitriol injection for the treatment of refractory secondary hyperparathyroidism in hemodialysis patients
by: GUO Jun-li, et al.
Published: (2020-01-01)

Effect of calcitriol on up-regulated expression of renin in renal tubular epithelial cells induced by high glucose
by: HAO Tian-ya, et al.
Published: (2016-01-01)

Calcitriol Treatment Decreases Cell Migration, Viability and β-Catenin Signaling in Oral Dysplasia
by: Daniel Peña-Oyarzún, et al.
Published: (2024-04-01)

Injectable hydrogel microsphere orchestrates immune regulation and bone regeneration via sustained release of calcitriol
by: Jiajun Chen, et al.
Published: (2025-06-01)

Effect of exogenous calcitriol on myopia development and axial length in guinea pigs with form deprivation myopia
by: Rongbin Liang, et al.
Published: (2024-05-01)

Capric Acid Behaves Agonistic Effect on Calcitriol to Control Inflammatory Mediators in Colon Cancer Cells
by: Amr Negm, et al.
Published: (2022-10-01)

Clinical effectiveness of calcitriol and calcium gluconate in treating older male patients with osteoporosis
by: Jinchun Zhang, et al.
Published: (2024-02-01)