Research progress on protein translational reprogramming in tumors
Protein translational reprogramming is an important compensatory change made by cells in response to a variety of stimuli, resulting in rapid, specific changes to the cellular proteome. In tumor cells, this reprogramming is regulated through several mechanisms, including the internal ribosome entry...
| Published in: | Jichu yixue yu linchuang |
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| Main Author: | |
| Format: | Article |
| Language: | Chinese |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2024-12-01
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| Subjects: | |
| Online Access: | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-12-1736.pdf |
| Summary: | Protein translational reprogramming is an important compensatory change made by cells in response to a variety of stimuli, resulting in rapid, specific changes to the cellular proteome. In tumor cells, this reprogramming is regulated through several mechanisms, including the internal ribosome entry site (IRES), cap-independent translational enhancers (CITE), and N6-methyladenosine (m6A) modifications. These processes play pivotal roles in controlling protein translational reprogramming, which is essential for tumorigenesis, progression, and treatment resistance. Further research into the function of protein translational reprogramming in tumors may reveal novel therapeutic targets and offer new avenues for cancer treatment. |
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| ISSN: | 1001-6325 |