Optimizing Design Parameters of PLA 3D-Printed Scaffolds for Bone Defect Repair

Current materials used to fill bone defects (ceramics, cement) either lack strength or do not induce bone repair. The use of biodegradable polymers such as PLA may promote patient healing by stimulating the production of new bone in parallel with a controlled degradation of the scaffold. This projec...

Full description

Bibliographic Details
Published in:	Surgeries
Main Authors:	Alexandrine Dussault, Audrey A. Pitaru, Michael H. Weber, Lisbet Haglund, Derek H. Rosenzweig, Isabelle Villemure
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Subjects:	scaffolds 3D-printing scaffolds design bone resection bone replacement PLA
Online Access:	https://www.mdpi.com/2673-4095/3/3/18

Similar Items

Fabrication, characterization and evaluating properties of 3D printed PLA-Mn scaffolds
by: Sina Dehghan-Toranposhti, et al.
Published: (2024-07-01)

Degradation mechanisms and acceleration strategies of poly (lactic acid) scaffold for bone regeneration
by: Pei Feng, et al.
Published: (2021-11-01)

Early stage prediction of bone regeneration using FEA and cell differentiation algorithms with 3D-printed PLA and PCL scaffolds: modeling and application to dorsal double-plating in distal radius fractures
by: Hsuan Chih Liu, et al.
Published: (2025-06-01)

Effect of extracellular matrix and dental pulp stem cells on bone regeneration with 3D printed PLA/HA composite scaffolds
by: I Gendviliene, et al.
Published: (2021-02-01)

Effect of the Addition of Inorganic Fillers on the Properties of Degradable Polymeric Blends for Bone Tissue Engineering
by: Stanisław Marecik, et al.
Published: (2024-08-01)

Design and analysis of 3D-printed PLA scaffolds: Enhancing mechanical properties
by: Aquib Rahman, et al.
Published: (2025-09-01)

Scaffolds for the repair of bone defects in clinical studies: a systematic review
by: Jian-Hua Zeng, et al.
Published: (2018-02-01)

In Vitro Characterization of 3D-Printed PLA/CPO Oxygen Releasing Scaffolds: Mechanical and Biological Properties for Bone Tissue Engineering
by: Abdullah Mohammed, et al.
Published: (2025-05-01)

Evaluation of Biocompatibility of PLA/PHB/TPS Polymer Scaffolds with Different Additives of ATBC and OLA Plasticizers
by: Marianna Trebuňová, et al.
Published: (2023-08-01)

Bone-Regenerating Capacity of Chitosan Membrane and Chitosan Foam Scaffolds in Critical Size Defects: In Vitro and In Vivo Study
by: Iman A. Fathy, et al.
Published: (2025-03-01)

A Combined Computational and Experimental Analysis of PLA and PCL Hybrid Nanocomposites 3D Printed Scaffolds for Bone Regeneration
by: Spyros V. Kallivokas, et al.
Published: (2024-01-01)

Analysis of the in vitro degradation and the in vivo tissue response to bi-layered 3D-printed scaffolds combining PLA and biphasic PLA/bioglass components – Guidance of the inflammatory response as basis for osteochondral regeneration
by: Mike Barbeck, et al.
Published: (2017-12-01)

Chitosan scaffolds for bone applications: a detailed review of main types, features and multifaceted uses
by: ZM Yao, et al.
Published: (2025-08-01)

In Vitro Biocompatibility Assessment of Bioengineered PLA-Hydrogel Core–Shell Scaffolds with Mesenchymal Stromal Cells for Bone Regeneration
by: Federica Re, et al.
Published: (2024-07-01)

Advances in 3D-printed scaffold technologies for bone defect repair: materials, biomechanics, and clinical prospects
by: Jie Sun, et al.
Published: (2025-04-01)

Comparison of Autografts and Biodegradable 3D-Printed Composite Scaffolds with Osteoconductive Properties for Tissue Regeneration in Bone Tuberculosis
by: Tatiana I. Vinogradova, et al.
Published: (2023-08-01)

The Co‐Incorporation of Zn/Cu or Zn/Co Ions Improves the Bone Regeneration Potential of PEOT/PBT–βTCP Composite 3D‐Printed Scaffolds
by: Martyna Nikody, et al.
Published: (2025-03-01)

Synthesis and Characterization of a Pla Scaffold with Pseudoboehmite and Graphene Oxide Nanofillers Added
by: Rafael Vieira Maidana, et al.
Published: (2025-01-01)

Evaluation of a Bioabsorbable Scaffold and Interlocked Nail System for Segmental Bone Defect
by: Morshed Khandaker, et al.
Published: (2023-03-01)

Chitosan-Based Biomaterial Scaffolds for the Repair of Infected Bone Defects
by: Yuhang Tian, et al.
Published: (2022-05-01)

In vivo characterization of 3D-printed polycaprolactone-hydroxyapatite scaffolds with Voronoi design to advance the concept of scaffold-guided bone regeneration
by: Markus Laubach, et al.
Published: (2023-10-01)

Cell-scaffold interactions in the bone tissue engineering triad
by: CM Murphy, et al.
Published: (2013-09-01)

Scaffold Guided Bone Regeneration for the Treatment of Large Segmental Defects in Long Bones
by: Frank Schulze, et al.
Published: (2023-01-01)

3D-printed bioceramic scaffolds for bone defect repair: bone aging and immune regulation
by: Haoran Qi, et al.
Published: (2025-03-01)

3D-printed PLA-Gr-Mg composite scaffolds for bone tissue engineering applications
by: Meysam Mohammadi-Zerankeshi, et al.
Published: (2023-01-01)

Electrospinning-based bone tissue scaffold construction: Progress and trends
by: Yunqi Ma, et al.
Published: (2025-04-01)

The Novel Use of a Custom Three-Dimensional-Printed Polycaprolactone-Tricalcium Phosphate Synthetic Bone Scaffold (Osteopore®) in the Management of a Critical-Sized Bone Defect for a Patient with an Open Intra-Articular Calcaneal Fracture – A Case Report
by: Ping Yen Yeo, et al.
Published: (2025-08-01)

Dual-functional 3D-printed porous bioactive scaffold enhanced bone repair by promoting osteogenesis and angiogenesis
by: Shaorong Li, et al.
Published: (2024-02-01)

Recent progress in 3D printing degradable polylactic acid‐based bone repair scaffold for the application of cancellous bone defect
by: Xulin Hu, et al.
Published: (2022-06-01)

Innovative modification strategies and emerging applications of natural hydrogel scaffolds for osteoporotic bone defect regeneration
by: Yanan Chen, et al.
Published: (2025-04-01)

Study on the influence of scaffold morphology and structure on osteogenic performance
by: Jingyu Zhou, et al.
Published: (2023-03-01)

Surface modifications of scaffolds for bone regeneration
by: Reihaneh Teimouri, et al.
Published: (2023-05-01)

Characterization and In Vitro Evaluation of Porous Polymer-Blended Scaffolds Functionalized with Tricalcium Phosphate
by: Iwona Pudełko-Prażuch, et al.
Published: (2024-02-01)

Mechanism research on a bioactive resveratrol–PLA–gelatin porous nano-scaffold in promoting the repair of cartilage defect
by: Yu F, et al.
Published: (2018-11-01)

Evaluating the Effect of Non-cellular Bioactive Glass-Containing Scaffolds on Osteogenesis and Angiogenesis in in vivo Animal Bone Defect Models
by: Chanuka D. S. Ranmuthu, et al.
Published: (2020-05-01)

Polycaprolactone as biomaterial for bone scaffolds: Review of literature
by: Ruby Dwivedi, et al.
Published: (2020-01-01)

Solvent/non-solvent treatment as a method for surface coating of poly(ε‑caprolactone) 3D-printed scaffolds with hydroxyapatite
by: Vadim S. Bocharov, et al.
Published: (2023-12-01)

3D printed Mg-incorporated polycaprolactone scaffolds for repairing rat skull defects
by: LI Xiaoye, LI Qiang, DAI Zhuo, DING Meng, DONG Heng, DONG Qiangsheng, BAI Jing, MOU Yongbin
Published: (2024-04-01)

3D printed Mg-incorporated polycaprolactone scaffolds for repairing rat skull defects
by: LI Xiaoye, et al.
Published: (2024-04-01)

Preparation of Diatom-Doped Bio-Nanocomposite Materials for Bone Tissue Scaffolds
by: Dicle Erden Gönenmiş, et al.
Published: (2022-09-01)