Evaluation Gene Expression of Kinase Insert Domain (KDR) as Prediction of Preeclampsia with Novel Biomarkers

Preeclampsia (PE) is the complexity the case of pregnancy with an indication of the presence of defective placentas, and inadequate blood supply to the placenta defect and endothelial dysfunction .the aim of study. The variation between endothelial growth factor angiogenesis (VEGF), placental growth...

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Bibliographic Details
Published in:Alfarama Journal of Basic & Applied Sciences
Main Authors: Ibrahim M. EL-Deen, Amal Seleem, Abdel Aziz Alrefaey, Elsherbiny Elsayed, Ateya Amin
Format: Article
Language:English
Published: Port Said University, Faculty of Sciences 2021-01-01
Subjects:
Preeclampsia
KDR
endothelial dysfunction
placental ischemia
Online Access:https://ajbas.journals.ekb.eg/article_110117_463c2dc50b81657d4f309209b6dd2809.pdf
Description
Summary:Preeclampsia (PE) is the complexity the case of pregnancy with an indication of the presence of defective placentas, and inadequate blood supply to the placenta defect and endothelial dysfunction .the aim of study. The variation between endothelial growth factor angiogenesis (VEGF), placental growth factor (PlGF) and their receptors kinase domain that contains the receptor (KDR) and tyrosine kinase 1 (Flt-1) plays a valuable role in the pathophysiology of PE .We conducted a cross-sectional study of 50 women with Preeclampsia: 25 women with mild PE, and 25 patients with severe PE. While 24 pregnant women work normally with age as a control group. placental mRNA gene expression of KDR was measured using real time PCR ( RT/PCR),The mean of KDR expression was statistically significantly higher in the control group compared to any of the PE groups (p < /p>
ISSN:2682-275X

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