Phylogeny of <i>Catabacter hongkongensis</i> Strains Responsible for Bacteremia Is Not Associated with Clinical Outcomes or Therapeutic Efficacy

<i>Catabacter hongkongensis</i> is a Gram-positive rod, isolated in 2007 in blood culture. Fewer than 15 infections have been reported. Herein, we present a lethal case of bacteremia due to <i>C. hongkongensis</i> identified through phylogenetic analyses. A woman was found un...

詳細記述

書誌詳細
出版年:Diseases
主要な著者: Matthieu Cabrol, Blandine Rammaert, Chloé Plouzeau, Christophe Burucoa, Maxime Pichon
フォーマット: 論文
言語:英語
出版事項: MDPI AG 2021-03-01
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オンライン・アクセス:https://www.mdpi.com/2079-9721/9/2/24
その他の書誌記述
要約:<i>Catabacter hongkongensis</i> is a Gram-positive rod, isolated in 2007 in blood culture. Fewer than 15 infections have been reported. Herein, we present a lethal case of bacteremia due to <i>C. hongkongensis</i> identified through phylogenetic analyses. A woman was found unconscious in a context of chronic diarrhea. An abdominal abscess with a hydroaeric level was discovered, associated with sigmoid adenocarcinoma and peritoneal carcinomatosis. Despite hospitalization in an ICU and the adaptation of antibiotic therapy, the patient died. Blood cultures were positive in the final stage of the disease (>60 h). Identification of <i>C. hongkongensis</i> was performed using 16S rDNA sequencing. Phylogenetic analyses did not enable classification of these strains according to clinical outcome or the antibiotic sensitivity to treatment. In this case, bacteria were difficult to isolate and MALDI-TOF remained non-contributive. As strains are resistant to probabilistic treatments, addition of metronidazole or vancomycin could optimize clinical management, highlighting the benefit of rapid molecular identification by sequencing.
ISSN:2079-9721