Selective preservation of anterior pituitary functions in patients with Sheehan′s syndrome

• 出版年: Indian Journal of Endocrinology and Metabolism
• 主要な著者: Bashir Ahmad Laway, Shahnaz Ahmad Mir, Tariq Gojwari, Tariq Rashid Shah, Abdul Hamid Zargar
• フォーマット: 論文
• 言語: 英語
• 出版事項: Wolters Kluwer Medknow Publications 2011-01-01
• 主題: Corticotrophs; empty sella; postpartum hemorrhage; regular cycles; Sheehan′s syndrome
• オンライン･アクセス: http://www.ijem.in/article.asp?issn=2230-8210;year=2011;volume=15;issue=7;spage=238;epage=241;aulast=Laway
• ISSN: 2230-8210; 2230-9500

Background: Sheehan′s syndrome manifests as hypopituitarism following a child birth usually preceded by postpartum hemorrhage. The symptoms range from vague feelings of ill health to symptoms of a full blown panhypopituitarism. A large series of such patients is not described in the literature. Materials and Methods: We present the details of ten women with partial Sheehan′s syndrome. They presented with post-partum hemorrhage and lactation failure. Results: After delivery, seven out of ten patients had regular menstrual cycles indicating preservation of gonadotroph function. Lactotroph, thyrotroph, and somatotroph failure were present in all and corticotrophs preservation was documented in four out of ten patients. The hypophysial magnetic resonance imaging (MRI) confirmed empty sella in all. Conclusion: lactotroph, somatotroph and thyrotroph failure are common in patients with Sheehan′s syndrome. In addition to known preservation of gonadotroph axis, corticotroph axis may be preserved in some of these patients arguing against the universal treatment of these patients with glucocorticoids.