High and low dose of luzindole or 4-phenyl-2-propionamidotetralin (4-P-PDOT) reverse bovine granulosa cell response to melatonin

Background Communication between oocytes and granulosa cells ultimately dictate follicle development or atresia. Melatonin is also involved in follicle development. This study aimed to investigate the effects of melatonin and its receptor antagonists on hormone secretion, as well as gene expression...

Full description

Bibliographic Details
Published in:	PeerJ
Main Authors:	Wenju Liu, Zhihao Chen, Rui Li, Menghao Zheng, Xunsheng Pang, Aiyou Wen, Bing Yang, Shujuan Wang
Format:	Article
Language:	English
Published:	PeerJ Inc. 2023-01-01
Subjects:	Melatonin Luzindole 4-P-PDOT Hormonal synthesis Gene regulation Bovine
Online Access:	https://peerj.com/articles/14612.pdf

Similar Items

Luzindole and 4P-PDOT block the effect of melatonin on bovine granulosa cell apoptosis and cell cycle depending on its concentration
by: Shujuan Wang, et al.
Published: (2021-03-01)

Acute blockade of endogenous melatonin by Luzindole, with or without peripheral LPS injection, induces jejunal inflammation and morphological alterations in Swiss mice
by: R.S. Matos, et al.
Published: (2021-08-01)

Melatonin Act as an Antidepressant via Attenuation of Neuroinflammation by Targeting Sirt1/Nrf2/HO-1 Signaling
by: Tahir Ali, et al.
Published: (2020-06-01)

Behavioral changes in the brown planthopper, Nilaparvata lugens, mediated by melatonin
by: Longqing Shi, et al.
Published: (2021-04-01)

Construction of Effective Nanosensor by Combining Semiconducting Polymer Dots with Diphenylcarbazide for Specific Recognition of Trace Cr (VI) Ion in Water and Vitro
by: Xilin Dou, et al.
Published: (2022-08-01)

RNAi-mediated knockdown of MTNR1B without disrupting the effects of melatonin on apoptosis and cell cycle in bovine granulose cells
by: Wenju Liu, et al.
Published: (2018-04-01)

Ratiometric pH Sensing and Imaging in Living Cells with Dual-Emission Semiconductor Polymer Dots
by: Piaopiao Chen, et al.
Published: (2019-08-01)

The effects of melatonin on bovine uniparental embryos development in vitro and the hormone secretion of COCs
by: Shujuan Wang, et al.
Published: (2017-07-01)

Gadolinium and Polythiophene Functionalized Polyurea Polymer Dots as Fluoro-Magnetic Nanoprobes
by: Soner Karabacak, et al.
Published: (2022-02-01)

Role of Melatonin in Bovine Reproductive Biotechnology
by: Zhiqiang Li, et al.
Published: (2023-06-01)

Administration of melatonin prior to modified synchronization protocol improves the productive and reproductive efficiency of Chinese crossbred buffaloes in low breeding season
by: Adili Abulaiti, et al.
Published: (2023-05-01)

Melatonin Implantation Improves the Reproductive Performance of Estrus-Synchronized Ewes During Seasonal Anestrus and Enhances the Antioxidant and Steroidogenic Capacities of Granulosa and Luteal Cells
by: Zengyi Duan, et al.
Published: (2025-07-01)

Melatonin Represses Mitophagy to Protect Mouse Granulosa Cells from Oxidative Damage
by: Yi Jiang, et al.
Published: (2021-06-01)

Modulation of Apoptosis and Autophagy by Melatonin in Juglone-Exposed Bovine Oocytes
by: Marwa El-Sheikh, et al.
Published: (2023-04-01)

The Role of Melatonin in Pregnancy and the Health Benefits for the Newborn
by: Rosita Verteramo, et al.
Published: (2022-12-01)

Melatonin reverses bisphenol A-induced toxicity in granulosa cells: Restoration of FSHR and connexin 43 expression
by: Ta-Chin Lin, et al.
Published: (2025-05-01)

Melatonin: biological significance and therapeutic properties
by: V. Rimšaitė, et al.
Published: (2022-09-01)

Melatonin: biological significance and therapeutic properties
by: V. Rimšaitė, et al.
Published: (2022-09-01)

Melatonin Ameliorates the Toxicity Induced by Deoxynivalenol in Murine Ovary Granulosa Cells by Antioxidative and Anti-Inflammatory Effects
by: Hairui Fan, et al.
Published: (2021-06-01)

Measuring of Plasma Melatonin Level in Patients with Preeclampsia
by: Maad M. Shalal, et al.
Published: (2017-10-01)

Beneficial Effects of Melatonin for the Newborn
by: Reza Saeidi
Published: (2024-10-01)

Melatonin-Mediated Suppression of mtROS-JNK-FOXO1 Pathway Alleviates Hypoxia-Induced Apoptosis in Porcine Granulosa Cells
by: Xuan Zhang, et al.
Published: (2023-10-01)

Melatonin and melatonin agonists to prevent and treat delirium in critical illness: a systematic review protocol
by: Jennifer Foster, et al.
Published: (2016-11-01)

Melatonin protects chicken follicular granulosa cells against oxidative damage-induced apoptosis via inhibiting FOXO1 signaling pathway
by: Xuelu Liu, et al.
Published: (2025-09-01)

Effects of photodynamic therapy using bisdemethoxycurcumin combined with melatonin or acetyl-melatonin on C. Albicans
by: Maria Margarita D. Duterte, et al.
Published: (2024-10-01)

Akdeniz Diyeti, Melatonin ve Sağlık
by: Merve Eda Eker, et al.
Published: (2018-09-01)

Chitosan–sEPDM and Melatonin–Chitosan–sEPDM Composite Membranes for Melatonin Transport and Release
by: Florentina Mihaela Păncescu, et al.
Published: (2023-02-01)

Melatonin Alleviates Hypoxia-Induced Apoptosis of Granulosa Cells by Reducing ROS and Activating MTNR1B–PKA–Caspase8/9 Pathway
by: Jing-Li Tao, et al.
Published: (2021-01-01)

Analgesic Effect of Melatonin in Mice
by: Imad Hashim Mohammad,
Published: (2012-12-01)

Melatonin Sources in Sheep Rumen and Its Role in Reproductive Physiology
by: Tian Niu, et al.
Published: (2024-11-01)

Comprehensive review of melatonin as a promising nutritional and nutraceutical supplement
by: Waad W. Kamfar, et al.
Published: (2024-01-01)

The Physiological Impact of Melatonin, Its Effect on the Course of Diseases and Their Therapy and the Effect of Magnetic Fields on Melatonin Secretion—Potential Common Pathways of Influence
by: Marta Woldańska-Okońska, et al.
Published: (2024-07-01)

The Effect of Melatonin on Body Weight and the Potential use of Melatonin as an Anti-Obesity Agent
by: Sama Atta Gitti, et al.
Published: (2023-08-01)

Influence of Melatonin on the state of immunity at psoriasis
by: V. S. Dmitruk, et al.
Published: (2009-08-01)

Melatonin: an anti-tumor agent for osteosarcoma
by: Hadis Fathizadeh, et al.
Published: (2019-11-01)

The ROS/SIRT1/STAR axis as a target for melatonin ameliorating atrazine-induced mitochondrial dysfunction and steroid disorders in granulosa cells
by: Xiao-Wei Li, et al.
Published: (2024-01-01)

Preliminary evidence that light through the eyelids can suppress melatonin and phase shift dim light melatonin onset
by: Figueiro Mariana G, et al.
Published: (2012-05-01)

Melatonin Improves The Developmental Competence of Goat Oocytes
by: Saghar Saeedabadi, et al.
Published: (2018-07-01)

Melatonin - A Cutaneous Perspective
by: Tapan Dhali, et al.
Published: (2021-10-01)

Melatonin - A Cutaneous Perspective
by: Tapan Dhali, et al.
Published: (2021-10-01)