Prediction of SARS-CoV-2 Omicron Variant Immunogenicity, Immune Escape and Pathogenicity, through the Analysis of Spike Protein-Specific Core Unique Peptides

The recently discovered Omicron variant of the SARS-CoV-2 coronavirus has raised a new, global, awareness. In this study, we identified the Core Unique Peptides (CrUPs) that reside exclusively in the Omicron variant of Spike protein and are absent from the human proteome, creating a new dataset of p...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Vaccines
المؤلفون الرئيسيون:	Evangelos Kontopodis, Vasileios Pierros, Dimitrios J. Stravopodis, George T. Tsangaris
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	MDPI AG 2022-02-01
الموضوعات:	core unique peptide COVID-19 immune escape infectiveness mutation Omicron variant
الوصول للمادة أونلاين:	https://www.mdpi.com/2076-393X/10/3/357

مواد مشابهة

Unique peptide signatures of SARS-CοV-2 virus against human proteome reveal variants’ immune escape and infectiveness
حسب: Vasileios Pierros, وآخرون
منشور في: (2022-04-01)

Virological Characteristics of the Omicron Variant: Key Mutations, Pathogenicity, and Immune Escape
حسب: CHEN Yuqing, وآخرون
منشور في: (2023-09-01)

Insight into SARS-CoV-2 Omicron variant immune escape possibility and variant independent potential therapeutic opportunities
حسب: Mohammad Shah Alam
منشور في: (2023-02-01)

SARS-CoV-2 omicron spike simulations: broad antibody escape, weakened ACE2 binding, and modest furin cleavage
حسب: M. Zaki Jawaid, وآخرون
منشور في: (2023-10-01)

Quantitative Characterization and Prediction of the Binding Determinants and Immune Escape Hotspots for Groups of Broadly Neutralizing Antibodies Against Omicron Variants: Atomistic Modeling of the SARS-CoV-2 Spike Complexes with Antibodies
حسب: Mohammed Alshahrani, وآخرون
منشور في: (2025-02-01)

Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape
حسب: Nash D. Rochman, وآخرون
منشور في: (2022-04-01)

The immune landscape and viral shedding of Omicron SARS-CoV-2 variants implicate immune escape
حسب: Weilong Zhang, وآخرون
منشور في: (2025-01-01)

SARS-CoV-2 Omicron BA.4/BA.5 Mutations in Spike Leading to T Cell Escape in Recently Vaccinated Individuals
حسب: Maarten E. Emmelot, وآخرون
منشور في: (2022-12-01)

Integrative Computational Modeling of Distinct Binding Mechanisms for Broadly Neutralizing Antibodies Targeting SARS-CoV-2 Spike Omicron Variants: Balance of Evolutionary and Dynamic Adaptability in Shaping Molecular Determinants of Immune Escape
حسب: Mohammed Alshahrani, وآخرون
منشور في: (2025-05-01)

On the Origins of Omicron’s Unique Spike Gene Insertion
حسب: A. J. Venkatakrishnan, وآخرون
منشور في: (2022-09-01)

Sub‐lineages of the SARS‐CoV‐2 Omicron variants: Characteristics and prevention
حسب: Ailan Xu, وآخرون
منشور في: (2022-09-01)

Multiscale Modeling and Dynamic Mutational Profiling of Binding Energetics and Immune Escape for Class I Antibodies with SARS-CoV-2 Spike Protein: Dissecting Mechanisms of High Resistance to Viral Escape Against Emerging Variants
حسب: Mohammed Alshahrani, وآخرون
منشور في: (2025-07-01)

Comprehending the model of omicron variant using fractional derivatives
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منشور في: (2023-12-01)

The landscape of antibody binding affinity in SARS-CoV-2 Omicron BA.1 evolution
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منشور في: (2023-02-01)

Immune Escape Associated with RBD Omicron Mutations and SARS-CoV-2 Evolution Dynamics
حسب: Aleksandr V. Kudriavtsev, وآخرون
منشور في: (2022-07-01)

The Difference in Wave Dynamics between SARS-CoV-2 Pre-Omicron and Omicron Variant Waves
حسب: Franz Konstantin Fuss, وآخرون
منشور في: (2022-12-01)

Challenges of SARS-CoV-2 Omicron Variant and appropriate countermeasures
حسب: Wenxia Shao, وآخرون
منشور في: (2022-06-01)

Deep Structural Analysis of Myriads of Omicron Sub-Variants Revealed Hotspot for Vaccine Escape Immunity
حسب: Valeria Gerardi, وآخرون
منشور في: (2023-03-01)

Allosteric Control Overcomes Steric Limitations for Neutralizing Antibodies Targeting Conserved Binding Epitopes of the SARS-CoV-2 Spike Protein: Exploring the Intersection of Binding, Allostery, and Immune Escape with a Multimodal Computational Approach
حسب: Mohammed Alshahrani, وآخرون
منشور في: (2025-09-01)

Quantum Chemical Computation of Omicron Mutations Near Cleavage Sites of the Spike Protein
حسب: Puja Adhikari, وآخرون
منشور في: (2022-10-01)

Predictors of reinfection with pre-Omicron and Omicron variants of concern among individuals who recovered from COVID-19 in the first year of the pandemic
حسب: Dani Cohen, وآخرون
منشور في: (2023-07-01)

Molecular mechanisms responsible for SARS-CoV-2 antibody waning and vaccine escape in Omicron sublineages BA.4 and BA.5
حسب: Benjamin Hewins, وآخرون
منشور في: (2022-07-01)

Mutation profiling, evolution analysis, molecular dynamics simulation, and functional characterization of Omicron sub-strains
حسب: Tian Gong, وآخرون
منشور في: (2025-10-01)

An updated review of epidemiological characteristics, immune escape, and therapeutic advances of SARS-CoV-2 Omicron XBB.1.5 and other mutants
حسب: Zongming Liu, وآخرون
منشور في: (2023-12-01)

Evaluation of the effectiveness of chemical inactivation and immunogenicity of the Omicron variant of the SARS-CoV-2 virus
حسب: Gulzhan A. Zhapparova, وآخرون
منشور في: (2024-11-01)

Origin and Reversion of Omicron Core Mutations in the Evolution of SARS-CoV-2 Genomes
حسب: Xinwei Zhao, وآخرون
منشور في: (2022-12-01)

The Global Epidemic of the SARS-CoV-2 Delta Variant, Key Spike Mutations and Immune Escape
حسب: Dandan Tian, وآخرون
منشور في: (2021-11-01)

Omicron SARS-CoV-2 Variant Spike Protein Shows an Increased Affinity to the Human ACE2 Receptor: An In Silico Analysis
حسب: Joseph Thomas Ortega, وآخرون
منشور في: (2021-12-01)

What do we know about pathological mechanism and pattern of lung injury related to SARS-CoV-2 Omicron variant?
حسب: Roberto Scendoni, وآخرون
منشور في: (2023-02-01)

Impact of Missense Mutations on Spike Protein Stability and Binding Affinity in the Omicron Variant
حسب: Vidhyanand Mahase, وآخرون
منشور في: (2024-07-01)

The D405N Mutation in the Spike Protein of SARS-CoV-2 Omicron BA.5 Inhibits Spike/Integrins Interaction and Viral Infection of Human Lung Microvascular Endothelial Cells
حسب: Antonella Bugatti, وآخرون
منشور في: (2023-01-01)

The omicron variant of SARS‐CoV‐2: Understanding the known and living with unknowns
حسب: Nicholas E. Ingraham, وآخرون
منشور في: (2021-12-01)

Immunogenicity and Breakthrough Outcomes of mRNA Booster Strategies Among Healthcare Workers During the BA.1/BA.2 Omicron Surge
حسب: Song Mi Moon, وآخرون
منشور في: (2025-10-01)

Antibody Response of Combination of BNT162b2 and CoronaVac Platforms of COVID-19 Vaccines against Omicron Variant
حسب: Ka-Wa Khong, وآخرون
منشور في: (2022-01-01)

Laryngo pharyngeal affection of COVID-19 during Delta and Omicron variant (Comparative Study)
حسب: Hanan Anwar, وآخرون
منشور في: (2024-08-01)

Characteristics of Omicron variant-induced SARS-CoV-2 reinfections in Chengdu, China
حسب: Yingxue DAI, وآخرون
منشور في: (2023-04-01)

Analysis and dynamical transmission of Covid-19 model by using Caputo-Fabrizio derivative
حسب: Muhammad Farman, وآخرون
منشور في: (2023-03-01)

Rational strategies for enhancing mAb binding to SARS-CoV-2 variants through CDR diversification and antibody-escape prediction
حسب: Masaud Shah, وآخرون
منشور في: (2023-03-01)

Clinical manifestations of SARS-CoV-2 Omicron infection is associated with the stage of liver cirrhosis
حسب: Fengjiao Wang, وآخرون
منشور في: (2025-04-01)

Resilience of Spike-Specific Immunity Induced by COVID-19 Vaccines against SARS-CoV-2 Variants
حسب: Laura Ballesteros-Sanabria, وآخرون
منشور في: (2022-04-01)