Cystine deprivation triggers CD36-mediated ferroptosis and dysfunction of tumor infiltrating CD8+ T cells

Abstract Cancer cells develop multiple strategies to evade T cell-mediated killing. On one hand, cancer cells may preferentially rely on certain amino acids for rapid growth and metastasis. On the other hand, sufficient nutrient availability and uptake are necessary for mounting an effective T cell...

Full description

Bibliographic Details
Published in:	Cell Death and Disease
Main Authors:	Chenfeng Han, Minmin Ge, Pengfei Xing, Tian Xia, Cangang Zhang, Kaili Ma, Yifu Ma, Shicheng Li, Wenhui Li, Xiaowei Liu, Baojun Zhang, Liyuan Zhang, Lianjun Zhang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-02-01
Online Access:	https://doi.org/10.1038/s41419-024-06503-1

Similar Items

Dihydrolipoamide dehydrogenase regulates cystine deprivation-induced ferroptosis in head and neck cancer
by: Daiha Shin, et al.
Published: (2020-02-01)

The cell cycle regulator p16 promotes tumor infiltrated CD8+ T cell exhaustion and apoptosis
by: Xin Zhang, et al.
Published: (2024-05-01)

Senescence-associated lysosomal dysfunction impairs cystine deprivation-induced lipid peroxidation and ferroptosis
by: Tze Mun Loo, et al.
Published: (2025-07-01)

BRAF D594A mutation defines a unique biological and immuno-modulatory subgroup associated with functional CD8+ T cell infiltration in colorectal cancer
by: Wenjing Li, et al.
Published: (2023-10-01)

CD36 promotes tubular ferroptosis by regulating the ubiquitination of FSP1 in acute kidney injury
by: Yixin Ma, et al.
Published: (2024-01-01)

Ferroptosis of CD163+ tissue-infiltrating macrophages and CD10+ PC+ epithelial cells in lupus nephritis
by: Qi Cheng, et al.
Published: (2023-07-01)

CD36-mediated ferroptosis destabilizes CD4+ T cell homeostasis in acute Stanford type-A aortic dissection
by: Hui Li, et al.
Published: (2024-09-01)

Rewiring Mitochondrial Metabolism for CD8+ T Cell Memory Formation and Effective Cancer Immunotherapy
by: Wenhui Li, et al.
Published: (2020-08-01)

Intermittent fasting inhibits ferroptosis by modulating CD36 and its palmitoylation to alleviate diabetic dry eye
by: Wenhui Wang, et al.
Published: (2026-03-01)

Targeting a disintegrin and metalloprotease (ADAM) 17-CD122 axis enhances CD8+ T cell effector differentiation and anti-tumor immunity
by: Lina Sun, et al.
Published: (2024-06-01)

Angiotensin II Induces Vascular Endothelial Dysfunction by Promoting Lipid Peroxidation-Mediated Ferroptosis via CD36
by: Qian Zhou, et al.
Published: (2024-11-01)

CD44 is involved in liver regeneration through enhanced uptake of extracellular cystine
by: Hyun Young Kim, et al.
Published: (2022-05-01)

Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
by: Zhennan Shi, et al.
Published: (2021-08-01)

Niraparib restricts intraperitoneal metastases of ovarian cancer by eliciting CD36-dependent ferroptosis
by: Ning Jin, et al.
Published: (2025-03-01)

CD36 aggravates ferroptosis in NK cells and dampens their anti-fibrotic activity in the liver
by: Xiaokun Shen, et al.
Published: (2026-05-01)

Tumor-infiltrating CD36+CD8+T cells determine exhausted tumor microenvironment and correlate with inferior response to chemotherapy in non-small cell lung cancer
by: Yong-Qiang Ao, et al.
Published: (2023-04-01)

Decreased CD8+ Lymphocytic Infiltration in Multifocal and Multicentric Glioblastomas
by: Run Wang, et al.
Published: (2021-09-01)

Author Correction: Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
by: Zhennan Shi, et al.
Published: (2023-02-01)

Synthesis and Biomedical Potential of Azapeptide Modulators of the Cluster of Differentiation 36 Receptor (CD36)
by: Caroline Proulx, et al.
Published: (2020-07-01)

Role of CD36 in central nervous system diseases
by: Min Feng, et al.
Published: (2024-01-01)

The Past and Present Lives of the Intraocular Transmembrane Protein CD36
by: Rucui Yang, et al.
Published: (2022-12-01)

CD36 and Its Role in Regulating the Tumor Microenvironment
by: Xinzhi Liao, et al.
Published: (2022-10-01)

Programmed death ligand 1 and tumor-infiltrating CD8+ T lymphocytes are associated with the clinical features in meningioma
by: Yaochuan Zhang, et al.
Published: (2022-11-01)

Impact of the interaction between the polymorphisms and hypermethylation of the CD36 gene on a new biomarker of type 2 diabetes mellitus: circulating soluble CD36 (sCD36) in Senegalese females
by: Maïmouna Touré, et al.
Published: (2022-08-01)

Prognostic significance of the infiltration of CD163+ macrophages combined with CD66b+ neutrophils in gastric cancer
by: Xiaopei Huang, et al.
Published: (2018-05-01)

The polymorphism analysis for CD36 among platelet donors
by: Qilu Lyu, et al.
Published: (2024-04-01)

The intrinsic role and mechanism of tumor expressed-CD38 on lung adenocarcinoma progression
by: Long Gao, et al.
Published: (2021-07-01)

FERROPTOSIS IN CD4+ AND CD8+ T-CELLS IN THE SETTINGS OF HIV INFECTION
by: Radoslava Emilova, et al.
Published: (2024-01-01)

CD36: The Bridge between Lipids and Tumors
by: Xuan Zhou, et al.
Published: (2024-01-01)

The function of CD36 in Mycobacterium tuberculosis infection
by: Jianjun Wang, et al.
Published: (2024-05-01)

Serum CD4 Is Associated with the Infiltration of CD4+T Cells in the Tumor Microenvironment of Gastric Cancer
by: Qi You, et al.
Published: (2021-01-01)

Cystine and Methionine Deficiency Promotes Ferroptosis by Inducing B-Cell Translocation Gene 1
by: Il-Je Cho, et al.
Published: (2021-09-01)

The cluster of differentiation-36 (CD-36) as a promising marker for many diseases
by: Omnia Ezzat, et al.
Published: (2021-01-01)

Infiltration by Intratumor and Stromal CD8 and CD68 in Cervical Cancer
by: Polina Dimitrova, et al.
Published: (2023-04-01)

Low CD36 and LOX-1 Levels and CD36 Gene Subexpression Are Associated with Metabolic Dysregulation in Older Individuals with Abdominal Obesity
by: Perla-Monserrat Madrigal-Ruíz, et al.
Published: (2016-01-01)

Circulating CD36 is reduced in HNF1A-MODY carriers.
by: Siobhan Bacon, et al.
Published: (2013-01-01)

Plasma levels of CD36 and glutathione as biomarkers for ruptured intracranial aneurysm
by: Wang Hanbin, et al.
Published: (2023-12-01)

PD-L1 and tumor-infiltrating CD8+ lymphocytes are correlated with clinical characteristics in pediatric and adolescent pituitary adenomas
by: Mengwu Shi, et al.
Published: (2023-06-01)

Correction: CD36 Participates in PrP-Induced Activation of Microglia.
by: Mohammed Kouadir, et al.
Published: (2012-01-01)

Elevated Interleukin-36α And CD4+IL-36α+T Cells Are Involved in the Pathogenesis of Graves' Disease
by: Qiu-ming Yao, et al.
Published: (2018-10-01)