Arsenic trioxide demonstrates efficacy in a mouse model of preclinical systemic sclerosis

Abstract Background Uncontrolled T-cell activation plays a key role in systemic sclerosis (SSc). Arsenic trioxide (ATO) has immunological effects and has demonstrated potential in preclinical SSc models. In this study, we assessed the efficacy of ATO in Fra2 transgenic (Fra2TG) mice, which develop s...

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Bibliographic Details
Published in:Arthritis Research & Therapy
Main Authors: Anne Cauvet, Arthur Decellas, Christophe Guignabert, Dominique Rongvaux-Gaïda, Raphaël Thuillet, Mina Ottaviani, Ly Tu, François Rieger, Jérôme Avouac, Yannick Allanore
Format: Article
Language:English
Published: BMC 2023-09-01
Subjects:
Systemic sclerosis
Arsenic trioxide
Pulmonary fibrosis
Pulmonary hypertension
Online Access:https://doi.org/10.1186/s13075-023-03143-2

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