Acute inhibition of hunger-sensing AgRP neurons promotes context-specific learning in mice

Objective: An environmental context, which reliably predicts food availability, can increase the appetitive food drive within the same environment context. However, hunger is required for the development of such a context-induced feeding (CIF) response, suggesting the neural circuits sensitive to hu...

Full description

Bibliographic Details
Published in:	Molecular Metabolism
Main Authors:	Felicia Reed, Alex Reichenbach, Harry Dempsey, Rachel E. Clarke, Mathieu Mequinion, Romana Stark, Sasha Rawlinson, Claire J. Foldi, Sarah H. Lockie, Zane B. Andrews
Format:	Article
Language:	English
Published:	Elsevier 2023-11-01
Subjects:	AgRP neurons Photometry Optogenetics Chemogenetics Hunger Conditioning
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877823001370

Similar Items

The Ghrelin-AgRP Neuron Nexus in Anorexia Nervosa: Implications for Metabolic and Behavioral Adaptations
by: Mathieu Méquinion, et al.
Published: (2020-01-01)

AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference
by: Nathaniel T. Nyema, et al.
Published: (2023-12-01)

AgRP neuron activity predicts and tracks the glycemic response to oral glucose
by: Micaela Glat, et al.
Published: (2026-06-01)

Identification of AgRP cells in the murine hindbrain that drive feeding
by: Tomas P. Bachor, et al.
Published: (2024-02-01)

Drp1 is required for AgRP neuronal activity and feeding
by: Sungho Jin, et al.
Published: (2021-03-01)

Optogenetic activation of hypothalamic AgRP neurons in transgenic zebrafish larvae increased food intake
by: Hossein Mehrabi, et al.
Published: (2025-05-01)

Microglia are required for developmental specification of AgRP innervation in the hypothalamus of offspring exposed to maternal high-fat diet during lactation
by: Haley N Mendoza-Romero, et al.
Published: (2025-06-01)

UCP2 mediates mitochondrial dynamics to induce AgRP neuronal activity
by: Sungho Jin, et al.
Published: (2025-09-01)

AgRP mediated calcium Inhibition of feeding via the vagal afferent nerve-brain pathway
by: Aru Su, et al.
Published: (2025-05-01)

Ghrelin signalling in AgRP neurons links metabolic state to the sensory regulation of AgRP neural activity
by: Wang Lok So, et al.
Published: (2023-12-01)

The p75 neurotrophin receptor in AgRP neurons is necessary for homeostatic feeding and food anticipation
by: Brandon Podyma, et al.
Published: (2020-01-01)

AgRP Neuron-Specific Ablation Represses Appetite, Energy Intake, and Somatic Growth in Larval Zebrafish
by: Chiu-Ya Lin, et al.
Published: (2023-02-01)

Acute elevated dietary fat alone is not sufficient to decrease AgRP projections in the paraventricular nucleus of the hypothalamus in mice
by: Selma Yagoub, et al.
Published: (2024-08-01)

Shank3 deficiency elicits autistic-like behaviors by activating p38α in hypothalamic AgRP neurons
by: Shanshan Wu, et al.
Published: (2024-04-01)

A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism
by: Yanlin He, et al.
Published: (2016-11-01)

Chemogenetic engagement of different GPCR signaling pathways segregates the orexigenic activity from the control of whole-body glucose metabolism by AGRP neurons
by: Valerie Espinal Abreu, et al.
Published: (2025-01-01)

The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis
by: Aykut Üner, et al.
Published: (2015-10-01)

CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
by: Sebastián Zagmutt, et al.
Published: (2023-03-01)

Dietary fat content and absorption shape standard diet devaluation through hunger circuits
by: Ames K. Sutton Hickey, et al.
Published: (2024-11-01)

Longan extract suppresses food intake through regulation of POMC/AgRP neuronal activities and endoplasmic reticulum stress in hypothalamus of db/db mice
by: Hyeyoon Eo, et al.
Published: (2023-06-01)

AgRP1 modulates breeding season-dependent feeding behavior in female medaka
by: Yurika Tagui, et al.
Published: (2025-05-01)

Effects of Thymoquinone on Hypothalamic NPY and AgRP Gene Expression in Intact and Hypothyroidism- Model Rats
by: Nasrin Ghahremani, et al.
Published: (2022-07-01)

RESTING PLASMA AgRP LEVELS RESPONSE TO EXERCISE-CONJUGATED DIET AND ONLY DIET IN OVERWEIGHT AND OBESE SEDENTARY FEMALES
by: Mahmoud Delphan, et al.
Published: (2012-01-01)

Inhibition of P2Y6 Signaling in AgRP Neurons Reduces Food Intake and Improves Systemic Insulin Sensitivity in Obesity
by: Sophie Marie Steculorum, et al.
Published: (2017-02-01)

Evidence That Agouti-Related Peptide May Directly Regulate Kisspeptin Neurons in Male Sheep
by: Christina M. Merkley, et al.
Published: (2021-02-01)

From Synapses to Circuits, Astrocytes Regulate Behavior
by: Krissy A. Lyon, et al.
Published: (2022-01-01)

Editorial: Optogenetic and chemogenetic insights on sensory stimulus detection to motivated behaviors and reinforcement
by: Anton Ilango, et al.
Published: (2023-04-01)

Mouse Microglial Calcitonin Receptor Knockout Impairs Hypothalamic Amylin Neuronal pSTAT3 Signaling but Lacks Major Metabolic Consequences
by: Bernd Coester, et al.
Published: (2022-01-01)

Inaugural Review Prize 2023: The exercise hyperpnoea dilemma: A 21st‐century perspective
by: Joseph F. Welch, et al.
Published: (2024-08-01)

Advanced approaches for selective investigation of neuronal function and circuitry: The future of developing novel therapeutic strategies in neuropharmacology?
by: Joksimović Srđan M., et al.
Published: (2023-01-01)

The Role of Physical Exercise to Improve the Browning of White Adipose Tissue via POMC Neurons
by: Kellen C. da Cruz Rodrigues, et al.
Published: (2018-03-01)

Regulation of body weight and food intake by AGRP neurons during opioid dependence and abstinence in mice
by: Brenton T. Laing, et al.
Published: (2022-08-01)

Live imaging of paracrine signaling: Advances in visualization and tracking techniques
by: Eriko Deguchi, et al.
Published: (2025-01-01)

Genetics‐Based Targeting Strategies for Precise Neuromodulation
by: Yuyuan He, et al.
Published: (2025-07-01)

Paraventricular oxytocin neurons impact energy intake and expenditure: projections to the bed nucleus of the stria terminalis reduce sucrose consumption
by: Amy A. Worth, et al.
Published: (2024-09-01)

Astrocytic Regulation of Neural Circuits Underlying Behaviors
by: Sun-Nyoung Hwang, et al.
Published: (2021-02-01)

Astrocytes in the Ventral Hippocampus Bidirectionally Regulate Innate and Stress‐Induced Anxiety‐Like Behaviors in Male Mice
by: Jing‐Ting Li, et al.
Published: (2024-10-01)

GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice
by: Srikanta Chowdhury, et al.
Published: (2019-06-01)

Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo
by: Yanbin Dong, et al.
Published: (2021-12-01)

Leptin signalling altered in infantile nephropathic cystinosis‐related bone disorder
by: Wai W. Cheung, et al.
Published: (2024-12-01)