Unmutated IGHV1-69 CLL Clone Displays a Distinct Gene Expression Profile by a Comparative qRT-PCR Assay

Chronic Lymphocytic Leukemia (CLL) is a heterogeneous disease characterized by variable clinical courses among different patients. This notion was supported by the possible coexistence of two or more independent CLL clones within the same patients, identified by the characterization of the B cell re...

Full description

Bibliographic Details
Published in:	Biomedicines
Main Authors:	Selena Mimmi, Domenico Maisano, Vincenzo Dattilo, Massimo Gentile, Federico Chiurazzi, Alessandro D’Ambrosio, Annamaria Zimbo, Nancy Nisticò, Annamaria Aloisio, Eleonora Vecchio, Giuseppe Fiume, Enrico Iaccino, Ileana Quinto
Format:	Article
Language:	English
Published:	MDPI AG 2022-03-01
Subjects:	B-cells chronic lymphocytic leukemia gene expression analysis CLL heterogeneity B-lymphoproliferative disorders phage display
Online Access:	https://www.mdpi.com/2227-9059/10/3/604

Similar Items

Role of Chronic Lymphocytic Leukemia (CLL)-Derived Exosomes in Tumor Progression and Survival
by: Nancy Nisticò, et al.
Published: (2020-09-01)

IGHV Mutational Status in a Cohort of Bulgarian CLL Patients: High Unmutated CLL Prevalence in North-East Bulgaria
by: Yosifova A, et al.
Published: (2024-09-01)

Evidence of somatic hypermutation in the antigen binding sites of patients with CLL harboring IGHV genes with 100% germline identity
by: Electra Sofou, et al.
Published: (2022-12-01)

Hypodiploidy: A Poor Prognostic Cytogenetic Marker in B-CLL
by: Andrew Ruggero, et al.
Published: (2025-07-01)

Phage-Displayed Peptides for Targeting Tyrosine Kinase Membrane Receptors in Cancer Therapy
by: Annamaria Aloisio, et al.
Published: (2021-04-01)

The Combination of Ibrutinib with BH3 Mimetics or Dichloroacetate Is Effective in B-CLL
by: Joaquín Marco-Brualla, et al.
Published: (2025-08-01)

Cytokine Release Ensuing Interaction Between Human Peripheral Blood Mononuclears and Epstein-Barr Virus Transformed B-CLL Cell Line
by: Hanna Bessler, et al.
Published: (2020-08-01)

NF-kB and the CLL microenvironment
by: Alice O’Donnell, et al.
Published: (2023-03-01)

Chronic Lymphocytic Leukemia (CLL)-Derived Extracellular Vesicles Educate Endothelial Cells to Become IL-6-Producing, CLL-Supportive Cells
by: Orit Uziel, et al.
Published: (2024-06-01)

Rare Coexistence of Atypical Chronic Lymphocytic Leukemia and B-Acute Lymphoblastic Leukemia in a Patient Followed Up for Monoclonal B-Cell Lymphocytosis
by: Fabio Bertani, et al.
Published: (2025-08-01)

Synthesis and Biochemical Evaluation of Ethanoanthracenes and Related Compounds: Antiproliferative and Pro-Apoptotic Effects in Chronic Lymphocytic Leukemia (CLL)
by: James P. McKeown, et al.
Published: (2024-08-01)

Challenges in Diagnosis and Clinical Management of COVID-19 in Patient with B-Cell Chronic Lymphocytic Leukemia (CLL): Report of One Case
by: Vincenzo Visco, et al.
Published: (2022-03-01)

A Retrospective Analysis of CLL Patients in a Romanian Hematology Center
by: Ana-Maria IORDAN, et al.
Published: (2025-06-01)

Students’ Perception on The Implementation of Orai Application In CLL Method in Teaching Speaking
by: Halimah, et al.
Published: (2022-05-01)

Rituximab maintenance overcomes the negative prognostic factor of obesity in CLL: Subgroup analysis of the international randomized AGMT CLL‐8a mabtenance trial
by: Alexander Egle, et al.
Published: (2019-04-01)

The Influence of CLL on EFL Learners’ Speaking Skill
by: Muhammad Ilyas
Published: (2018-08-01)

Spotlight on borderline-IGHV mutational status in chronic lymphocytic leukemia
by: Souraya Rammal, et al.
Published: (2024-06-01)

Case report: HSV lymphadenitis in immunocompromised patient with CLL
by: Talal Al-Assil, et al.
Published: (2024-12-01)

CLL stereotyped B-cell receptor immunoglobulin sequences are recurrent in the B-cell repertoire of healthy individuals: Apparent lack of central and early peripheral tolerance censoring
by: Stefano Vergani, et al.
Published: (2023-03-01)

Uncovering the Exosomes Diversity: A Window of Opportunity for Tumor Progression Monitoring
by: Domenico Maisano, et al.
Published: (2020-08-01)

Progressive multifocal leukoencephalopathy in a patient with B-cell chronic lymphocytic leukemia after COVID-19 vaccination, complicated with COVID-19 and mucormycosis: a case report
by: Hamed Amirifard, et al.
Published: (2024-05-01)

Successful treatment of a CLL associated IgM hyper-viscosity syndrome: A rare case
by: Toufic Tannous, et al.
Published: (2024-01-01)

B cell M-CLL clones retain selection against replacement mutations in their immunoglobulin gene framework regions
by: Hadas Neuman, et al.
Published: (2023-03-01)

Chronic Lymphoproliferative Disorders at an Indian Tertiary Cancer Centre — The Panel Sufficiency in the Diagnosis of Chronic Lymphocytic Leukaemia
by: Geeta V Patil Okaly, et al.
Published: (2013-07-01)

Current strategies for the diagnosis and management of chronic lymphocytic leukemia (CLL), with a focus on poor-risk CLL: A review
by: Fabienne Mc Clanahan, et al.
Published: (2011-05-01)

Current strategies for the diagnosis and management of chronic lymphocytic leukemia (CLL), with a focus on poor-risk CLL: A review
by: Fabienne Mc Clanahan, et al.
Published: (2011-06-01)

Venetoclax-Based Regimens in CLL: Immunoglobulin G Levels, Absolute Neutrophil Counts, and Infectious Complications
by: Wojciech Szlasa, et al.
Published: (2025-06-01)

Opinion: What defines high-risk CLL in the post-chemoimmunotherapy era?
by: Jennifer Edelmann, et al.
Published: (2023-02-01)

Effect of Curcumin on Growth Inhibition and Gene Expression Reduction in Chronic Lymphocytic Leukemia Cells(CLL-CII)
by: AM Gholamian, et al.
Published: (2020-04-01)

Diagnosis of B-CLL Leukemia Using Fractal Dimension
by: Tohid Yousefzadeh Hassanluie, et al.
Published: (2017-07-01)

Frontline Treatment of the Young, Fit Patient with CLL: A Canadian Perspective
by: Jacqueline Costello, et al.
Published: (2021-09-01)

Development of Cyclic Peptides Targeting the Epidermal Growth Factor Receptor in Mesenchymal Triple-Negative Breast Cancer Subtype
by: Nancy Nisticò, et al.
Published: (2023-04-01)

Warehouse-based, immunopeptidome-guided design of personalised peptide vaccines shows feasibility in clinical trial evaluation in CLL patients
by: Jonas S. Heitmann, et al.
Published: (2024-11-01)

Celebrating 20 Years of IGHV Mutation Analysis in CLL
by: Nicholas Chiorazzi, et al.
Published: (2020-02-01)

Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study
by: Eleonora Roncaglia, et al.
Published: (2025-07-01)

Effect of IGHV Gene Mutation Status and BCR Structure Stereotypy on Effectiveness of BR Regimen in First-Line Therapy of Chronic Lymphocytic Leukemia
by: VV Strugov, et al.
Published: (2017-04-01)

EUROCOVER-CLL: Reimbursement and accessibility of new treatments in relapsed/refractory chronic lymphocytic leukemia
by: Magdalena Monica, et al.
Published: (2025-09-01)

BTLA Expression in CLL: Epigenetic Regulation and Impact on CLL B Cell Proliferation and Ability to IL-4 Production
by: Lidia Karabon, et al.
Published: (2021-11-01)

The malignant transformation potential of the oncogene STYK1/NOK at early lymphocyte development in transgenic mice
by: Yin Yang, et al.
Published: (2024-07-01)

Proteolysis Targeting Chimeras for BTK Efficiently Inhibit B-Cell Receptor Signaling and Can Overcome Ibrutinib Resistance in CLL Cells
by: Yamit Shorer Arbel, et al.
Published: (2021-05-01)