Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in DN

ABSTRACT Background Diabetic nephropathy (DN) is a severe microvascular complication of diabetes with a complex pathogenesis. Methods Recent studies were reviewed to explore the role of gut microbiota and its metabolites in DN development. Results Dysbiosis of gut bacteria contributes to pathologica...

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Bibliographic Details
Published in:Journal of Diabetes
Main Authors: Jinzhou Liu, Min Guo, Xiaobin Yuan, Xiao Fan, Jin Wang, Xiangying Jiao
Format: Article
Language:English
Published: Wiley 2025-04-01
Subjects:
diabetic nephropathy
gut microbiota
gut–kidney axis
microbial metabolites
novel biomarkers
Online Access:https://doi.org/10.1111/1753-0407.70068
Description
Summary:ABSTRACT Background Diabetic nephropathy (DN) is a severe microvascular complication of diabetes with a complex pathogenesis. Methods Recent studies were reviewed to explore the role of gut microbiota and its metabolites in DN development. Results Dysbiosis of gut bacteria contributes to pathological changes such as glomerular sclerosis and renal tubule injury. Microbial metabolites are involved in DN through immune and inflammatory pathways. Conclusions Understanding the relationship between gut microbiota, its metabolites, and DN may offer potential implications for DN diagnosis, prevention, and treatment. Translating this knowledge into clinical practice presents challenges and opportunities.
ISSN:1753-0393
1753-0407

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