Enhanced TrkA signaling impairs basal forebrain-dependent behavior

Basal forebrain cholinergic neurons (BFCNs) modulate cognitive functions such as attention, learning and memory. The NGF/TrkA pathway plays an important role in the development and function of BFCNs, although two mouse models conditionally deleting TrkA expression in the central nervous system (CNS)...

Full description

Bibliographic Details

Published in:	Frontiers in Molecular Neuroscience
Main Authors:	Laura Calvo-Enrique, Silvia Lisa, Cristina Vicente-García, Ruben Deogracias, Juan Carlos Arévalo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-09-01
Subjects:	TrkA NGF (nerve growth factor) basal forebrain cholinergic neurons mice behavior learning
Online Access:	https://www.frontiersin.org/articles/10.3389/fnmol.2023.1266983/full