The first imported case of Rift Valley fever in China reveals a genetic reassortment of different viral lineages
We report the first imported case of Rift Valley fever (RVF) in China. The patient returned from Angola, a non-epidemic country, with an infection of a new reassortant from different lineages of Rift Valley fever viruses (RVFVs). The patient developed multiorgan dysfunction and gradually recovered w...
| Published in: | Emerging Microbes and Infections |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Online Access: | https://www.tandfonline.com/doi/10.1038/emi.2016.136 |
| _version_ | 1851869195810111488 |
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| author | Jingyuan Liu Yulan Sun Weifeng Shi Shuguang Tan Yang Pan Shujuan Cui Qingchao Zhang Xiangfeng Dou Yanning Lv Xinyu Li Xitai Li Lijuan Chen Chuansong Quan Qianli Wang Yingze Zhao Qiang lv Wenhao Hua Hui Zeng Zhihai Chen Haofeng Xiong Chengyu Jiang Xinghuo Pang Fujie Zhang Mifang Liang Guizhen Wu George F Gao William J Liu Ang Li Quanyi Wang |
| author_facet | Jingyuan Liu Yulan Sun Weifeng Shi Shuguang Tan Yang Pan Shujuan Cui Qingchao Zhang Xiangfeng Dou Yanning Lv Xinyu Li Xitai Li Lijuan Chen Chuansong Quan Qianli Wang Yingze Zhao Qiang lv Wenhao Hua Hui Zeng Zhihai Chen Haofeng Xiong Chengyu Jiang Xinghuo Pang Fujie Zhang Mifang Liang Guizhen Wu George F Gao William J Liu Ang Li Quanyi Wang |
| author_sort | Jingyuan Liu |
| collection | DOAJ |
| container_title | Emerging Microbes and Infections |
| description | We report the first imported case of Rift Valley fever (RVF) in China. The patient returned from Angola, a non-epidemic country, with an infection of a new reassortant from different lineages of Rift Valley fever viruses (RVFVs). The patient developed multiorgan dysfunction and gradually recovered with continuous renal replacement therapy and a short regimen of methylprednisolone treatment. The disordered cytokines and chemokines in the plasma of the patient revealed hypercytokinemia, but the levels of protective cytokines were low upon admission and fluctuated as the disease improved. Whole-genome sequencing and phylogenetic analysis revealed that the imported strain was a reassortant comprising the L and M genes from lineage E and the S gene from lineage A. This case highlights that RVFV had undergone genetic reassortment, which could potentially alter its biological properties, cause large outbreaks and pose a serious threat to global public health as well as the livestock breeding industry.Emerging Microbes & Infections (2017) 6, e4; doi:10.1038/emi.2016.136; published online 18 January 2017 |
| format | Article |
| id | doaj-art-9b7c00aab38d47cdb3393fb5be6717bf |
| institution | Directory of Open Access Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| spelling | doaj-art-9b7c00aab38d47cdb3393fb5be6717bf2025-08-19T22:17:26ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512017-01-01611710.1038/emi.2016.136The first imported case of Rift Valley fever in China reveals a genetic reassortment of different viral lineagesJingyuan Liu0Yulan Sun1Weifeng Shi2Shuguang Tan3Yang Pan4Shujuan Cui5Qingchao Zhang6Xiangfeng Dou7Yanning Lv8Xinyu Li9Xitai Li10Lijuan Chen11Chuansong Quan12Qianli Wang13Yingze Zhao14Qiang lv15Wenhao Hua16Hui Zeng17Zhihai Chen18Haofeng Xiong19Chengyu Jiang20Xinghuo Pang21Fujie Zhang22Mifang Liang23Guizhen Wu24George F Gao25William J Liu26Ang Li27Quanyi Wang28Beijing Ditan HospitalCapital Medical University, Beijing 100015, ChinaInstitute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, ChinaInstitute of Pathogen BiologyTaishan Medical College, Taian 271000, ChinaKey Laboratory of Pathogenic Microbiology and Immunology, Institute of MicrobiologyChinese Academy of Sciences, Beijing 100101, ChinaInstitute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, ChinaInstitute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, ChinaState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical SciencesChinese Academy of Medical Sciences, Beijing 100005, ChinaInstitute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, ChinaInstitute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, ChinaInstitute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, ChinaInstitute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, ChinaInstitute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, ChinaNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention, Beijing 102206, ChinaKey Laboratory of Pathogenic Microbiology and Immunology, Institute of MicrobiologyChinese Academy of Sciences, Beijing 100101, ChinaNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention, Beijing 102206, ChinaInstitute of Pathogen BiologyTaishan Medical College, Taian 271000, ChinaBeijing Ditan HospitalCapital Medical University, Beijing 100015, ChinaBeijing Ditan HospitalCapital Medical University, Beijing 100015, ChinaBeijing Ditan HospitalCapital Medical University, Beijing 100015, ChinaBeijing Ditan HospitalCapital Medical University, Beijing 100015, ChinaState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical SciencesChinese Academy of Medical Sciences, Beijing 100005, ChinaInstitute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, ChinaBeijing Ditan HospitalCapital Medical University, Beijing 100015, ChinaNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention, Beijing 102206, ChinaNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention, Beijing 102206, ChinaKey Laboratory of Pathogenic Microbiology and Immunology, Institute of MicrobiologyChinese Academy of Sciences, Beijing 100101, ChinaNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention, Beijing 102206, ChinaBeijing Ditan HospitalCapital Medical University, Beijing 100015, ChinaInstitute for Infectious Disease and Endemic Disease ControlBeijing Center for Disease Prevention and Control, Beijing 100013, ChinaWe report the first imported case of Rift Valley fever (RVF) in China. The patient returned from Angola, a non-epidemic country, with an infection of a new reassortant from different lineages of Rift Valley fever viruses (RVFVs). The patient developed multiorgan dysfunction and gradually recovered with continuous renal replacement therapy and a short regimen of methylprednisolone treatment. The disordered cytokines and chemokines in the plasma of the patient revealed hypercytokinemia, but the levels of protective cytokines were low upon admission and fluctuated as the disease improved. Whole-genome sequencing and phylogenetic analysis revealed that the imported strain was a reassortant comprising the L and M genes from lineage E and the S gene from lineage A. This case highlights that RVFV had undergone genetic reassortment, which could potentially alter its biological properties, cause large outbreaks and pose a serious threat to global public health as well as the livestock breeding industry.Emerging Microbes & Infections (2017) 6, e4; doi:10.1038/emi.2016.136; published online 18 January 2017https://www.tandfonline.com/doi/10.1038/emi.2016.136hypercytokinemiaimported casereassortmentRift Valley fever virus |
| spellingShingle | Jingyuan Liu Yulan Sun Weifeng Shi Shuguang Tan Yang Pan Shujuan Cui Qingchao Zhang Xiangfeng Dou Yanning Lv Xinyu Li Xitai Li Lijuan Chen Chuansong Quan Qianli Wang Yingze Zhao Qiang lv Wenhao Hua Hui Zeng Zhihai Chen Haofeng Xiong Chengyu Jiang Xinghuo Pang Fujie Zhang Mifang Liang Guizhen Wu George F Gao William J Liu Ang Li Quanyi Wang The first imported case of Rift Valley fever in China reveals a genetic reassortment of different viral lineages hypercytokinemia imported case reassortment Rift Valley fever virus |
| title | The first imported case of Rift Valley fever in China reveals a genetic reassortment of different viral lineages |
| title_full | The first imported case of Rift Valley fever in China reveals a genetic reassortment of different viral lineages |
| title_fullStr | The first imported case of Rift Valley fever in China reveals a genetic reassortment of different viral lineages |
| title_full_unstemmed | The first imported case of Rift Valley fever in China reveals a genetic reassortment of different viral lineages |
| title_short | The first imported case of Rift Valley fever in China reveals a genetic reassortment of different viral lineages |
| title_sort | first imported case of rift valley fever in china reveals a genetic reassortment of different viral lineages |
| topic | hypercytokinemia imported case reassortment Rift Valley fever virus |
| url | https://www.tandfonline.com/doi/10.1038/emi.2016.136 |
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