SOX9 Is Highly Expressed in Nonampullary Duodenal Adenoma and Adenocarcinoma in Humans

• Published in: Gut and Liver
• Format: Article
• Language: English
• Published: Gastroenterology Council for Gut and Liver 2013-09-01
• Subjects: sox9; duodenal adenoma; duodenal adenocarcinoma
• Online Access: http://gutnliver.org/journal/view.html?doi=10.5009/gnl.2013.7.5.513
• ISSN: 1976-2283

Background/AimsSOX9 is a marker for stem cells in the intestine, and overexpression of SOX9 is found in gastric and colon cancer; however, the expression of SOX9 in nonampullary duodenal adenoma and adenocarcinoma has not yet been evaluated. This study aimed to investigate SOX9 expression in nonampullary duodenal adenoma and adenocarcinoma by immunohistochemistry.Methods : We evaluated SOX9 expression in 43 clinical samples (nonampullary duodenal adenoma in 22 lesions and nonampullary duodenal adenocarcinoma in 21 lesions) resected under endoscopic mucosal resection or endoscopic submucosal dissection.Results : SOX9 was expressed in part of the base of the normal duodenal mucosa surrounding adenomas and adenocarcinomas. In contrast, SOX9-positive cells were found in more than half of the crypts from the bottom part of the crypt in all of the 43 samples. Moreover, in 15 adenoma samples (68.2%) and 19 carcinoma samples (90.5%), SOX9 was expressed in more than three-quarters of the crypts from the bottom part of the crypt.Conclusion : sSOX9 is overexpressed in nonampullary duodenal adenoma and adenocarcinoma in humans.