Efficacy of Anakinra Treatment in two Moroccan Patients With Mevalonate Kinase Deficiency
Mevalonate kinase deficiency (MKD) is a rare hereditary autoinflammatory disease, with a widely variable clinical spectrum. It is characterized by febrile recurrent episodes and systemic inflammation. Data on therapeutic options for MKD are still limited and remain unknown in our country. We report...
| Published in: | Global Pediatric Health |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-10-01
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| Online Access: | https://doi.org/10.1177/2333794X231207351 |
| _version_ | 1851887113743630336 |
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| author | Manal Souali Asmaa Sakhi Ahmed Aziz Bousfiha Kenza Bouayed |
| author_facet | Manal Souali Asmaa Sakhi Ahmed Aziz Bousfiha Kenza Bouayed |
| author_sort | Manal Souali |
| collection | DOAJ |
| container_title | Global Pediatric Health |
| description | Mevalonate kinase deficiency (MKD) is a rare hereditary autoinflammatory disease, with a widely variable clinical spectrum. It is characterized by febrile recurrent episodes and systemic inflammation. Data on therapeutic options for MKD are still limited and remain unknown in our country. We report Moroccan cases with MKD referred in our unit and treated with Anakinra, an interleukin-1 receptor antagonist. Through this study, we evaluate the efficacy of this bioagent, in our 2 MKD patients, in whom Anakinra has shown a complete clinical remission, with a remaining mild inflammation for one case, and normalization of growth with rare episodes of cervical adenopathies for the second case. Our experience provides an additional argument supporting the efficacy of Anakinra treatment, demonstrated previously but still lacks of objective data. |
| format | Article |
| id | doaj-art-9bbbafd7b6d54327b5d09c7ddf2020bf |
| institution | Directory of Open Access Journals |
| issn | 2333-794X |
| language | English |
| publishDate | 2023-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| spelling | doaj-art-9bbbafd7b6d54327b5d09c7ddf2020bf2025-08-19T22:11:07ZengSAGE PublishingGlobal Pediatric Health2333-794X2023-10-011010.1177/2333794X231207351Efficacy of Anakinra Treatment in two Moroccan Patients With Mevalonate Kinase DeficiencyManal Souali0Asmaa Sakhi1Ahmed Aziz Bousfiha2Kenza Bouayed3Laboratory of Clinical Immunology, Inflammation and Allergy (LICIA), Hassan II University - Faculty of Medicine and Pharmacy of Casablanca, MoroccoPediatric Rheumatology and Internal Medicine Unit, Abderrahim Harouchi Mother and Child Hospital, CHU Ibn Rochd, Hassan II University - Casablanca, MoroccoClinical Immunology and Infectious Diseases Unit, Abderrahim Harouchi Mother and Child Hospital, CHU Ibn Rochd, Hassan II University - Casablanca, MoroccoPediatric Rheumatology and Internal Medicine Unit, Abderrahim Harouchi Mother and Child Hospital, CHU Ibn Rochd, Hassan II University - Casablanca, MoroccoMevalonate kinase deficiency (MKD) is a rare hereditary autoinflammatory disease, with a widely variable clinical spectrum. It is characterized by febrile recurrent episodes and systemic inflammation. Data on therapeutic options for MKD are still limited and remain unknown in our country. We report Moroccan cases with MKD referred in our unit and treated with Anakinra, an interleukin-1 receptor antagonist. Through this study, we evaluate the efficacy of this bioagent, in our 2 MKD patients, in whom Anakinra has shown a complete clinical remission, with a remaining mild inflammation for one case, and normalization of growth with rare episodes of cervical adenopathies for the second case. Our experience provides an additional argument supporting the efficacy of Anakinra treatment, demonstrated previously but still lacks of objective data.https://doi.org/10.1177/2333794X231207351 |
| spellingShingle | Manal Souali Asmaa Sakhi Ahmed Aziz Bousfiha Kenza Bouayed Efficacy of Anakinra Treatment in two Moroccan Patients With Mevalonate Kinase Deficiency |
| title | Efficacy of Anakinra Treatment in two Moroccan Patients With Mevalonate Kinase Deficiency |
| title_full | Efficacy of Anakinra Treatment in two Moroccan Patients With Mevalonate Kinase Deficiency |
| title_fullStr | Efficacy of Anakinra Treatment in two Moroccan Patients With Mevalonate Kinase Deficiency |
| title_full_unstemmed | Efficacy of Anakinra Treatment in two Moroccan Patients With Mevalonate Kinase Deficiency |
| title_short | Efficacy of Anakinra Treatment in two Moroccan Patients With Mevalonate Kinase Deficiency |
| title_sort | efficacy of anakinra treatment in two moroccan patients with mevalonate kinase deficiency |
| url | https://doi.org/10.1177/2333794X231207351 |
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