Ascorbic acid effect on morphine withdrawal symptoms in rats
Introduction: Today, drug addiction is an important healthcare issue. Any helps to drug withdrawal may decrease its prevalence in the society. Ascorbic acid is a component, which can affect neurotransmitter systems as a regulator along with its cofactor role. Noradrenergic and dopaminergic system...
| Published in: | Journal of Craniomaxillofacial Research |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2021-07-01
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| Subjects: | |
| Online Access: | https://jcr.tums.ac.ir/index.php/jcr/article/view/365 |
| Summary: | Introduction: Today, drug addiction is an important healthcare issue. Any helps to drug withdrawal
may decrease its prevalence in the society. Ascorbic acid is a component, which can affect
neurotransmitter systems as a regulator along with its cofactor role. Noradrenergic and dopaminergic
systems are two important neurotransmitter systems in the opiate withdrawal syndrome. It
seems that ascorbic acid can decrease the symptoms of opiate withdrawal through regulating the
related systems. In this regard, the current study aimed to evaluate the effect of ascorbic acid on the
symptoms of morphine withdrawal in Syrian mice.
Materials and Methods: Male Syrian mice in eight experimental groups received incremental
doses of morphine as 10, 20, 30 and 40mg/kg within the first, second, third, and fourth
days of the experiment, respectively, through intraperitoneal injection, twice a day, and the control
group received and equal amount of saline. On the fifth day, six groups of morphine addicts received
ascorbic acid with six doses of 10, 50, 100, 200, 400 and 800mg/kg through intraperitoneal
injection. Then, naloxone 2mg/kg was injected to all groups including morphine alone and morphine
with acute does of ascorbic acid. Then, withdrawal symptoms were evaluated for 30 minutes.
Results: Administration of an acute dose of ascorbic acid reduced dose dependent withdrawal
symptoms in such a way that 10, 50, and 100mg/kg doses of ascorbic acid reduced “writhing”
symptom, 200mg/kg reduced “jumping” symptom, and 400 and 800mg/kg reduced “climbing,
jumping, and standing” symptoms.
Conclusion: It seems that ascorbic acid administration can improve the symptoms of opiate
withdrawal syndrome. More studies on human population can also indicate the therapeutic effect
of ascorbic acid on drug withdrawal.
Keywords: Addiction; Morphine; Withdrawal syndrome; Ascorbic acid. |
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| ISSN: | 2345-5489 2345-6213 |