Comprehensive analysis of molecular markers linked to antimalarial drug resistance in Plasmodium falciparum in Northern, Northeastern and Eastern Uganda

Abstract Background In Uganda, antimalarial resistance in Plasmodium falciparum poses serious public health and treatment challenges. Globally, recent data have highlighted the roles of following genes in malaria resistance: Plasmodium falciparum dihydrofolate reductase (Pfdhfr), Plasmodium falcipar...

Full description

Bibliographic Details
Published in:	Malaria Journal
Main Authors:	Peter Olupot-Olupot, George Paasi, Thomas Katairo, Jimmy Patrick Alunyo, Alice Nakiyemba, Gilbert Gilibrays Ocen, Stephen Pande, Florance Alaroker, William Okiror, Emmaluel Ocen, Alex Oula, Charles Benard Okalebo, Ongodia Paul, Denis Amorut, Stephen Tukwasibwe, Susan Nabadda Ndidde, Isaac Sewanyana, Samuel L. Nsobya
Format:	Article
Language:	English
Published:	BMC 2025-06-01
Subjects:	Antimalarial resistance Uganda Pfk13 Pfdhfr Pfdhps Pfmdr1 Pfcrt
Online Access:	https://doi.org/10.1186/s12936-025-05439-x

Similar Items

Efficacy of artemether-lumefantrine in treatment of malaria among under-fives and prevalence of drug resistance markers in Igombe-Mwanza, north-western Tanzania
by: Kamugisha Erasmus, et al.
Published: (2012-02-01)

Efficacy of artemether-lumefantrine for treating uncomplicated Plasmodium falciparum cases and molecular surveillance of drug resistance genes in Western Myanmar
by: Yanrui Wu, et al.
Published: (2020-08-01)

Assessment of Plasmodium falciparum drug resistance associated molecular markers in Mandla, Madhya Pradesh, India
by: Akansha Singh, et al.
Published: (2023-12-01)

Prevalence of Plasmodium falciparum antimalarial drug resistance genes in Southeastern Gabon from 2011 to 2014
by: Voumbo-Matoumona DF, et al.
Published: (2018-08-01)

Allelic frequencies of mutants of the Plasmodium falciparum, quinoline and folate metabolizing genes in the west region of Cameroon
by: Innocent Mbulli Ali, et al.
Published: (2022-11-01)

A Narrative Review on the Prevalence of <i>Plasmodium falciparum</i> Resistance Mutations to Antimalarial Drugs in Rwanda
by: Muharib Alruwaili, et al.
Published: (2025-03-01)

Assessment of Plasmodium falciparum drug resistance molecular markers from the Blue Nile State, Southeast Sudan
by: Abdelrahim O. Mohamed, et al.
Published: (2020-02-01)

Malaria in Venezuela: changes in the complexity of infection reflects the increment in transmission intensity
by: M. Andreína Pacheco, et al.
Published: (2020-05-01)

Polymorphisms in the Pfcrt, Pfmdr1, and Pfk13 genes of Plasmodium falciparum isolates from southern Brazzaville, Republic of Congo
by: Marcel Tapsou Baina, et al.
Published: (2024-11-01)

Evolution of genetic markers for drug resistance after the introduction of dihydroartemisinin–piperaquine as first-line anti-malarial treatment for uncomplicated falciparum malaria in Indonesia
by: Farindira Vesti Rahmasari, et al.
Published: (2023-08-01)

Prevalence of Mutations in the <i>Pfdhfr</i>, <i>Pfdhps,</i> and <i>Pfmdr1</i> Genes of Malarial Parasites Isolated from Symptomatic Patients in Dogondoutchi, Niger
by: Ibrahima Issa, et al.
Published: (2022-07-01)

Molecular characterization of Plasmodium falciparum antifolate resistance markers in Thailand between 2008 and 2016
by: Rungniran Sugaram, et al.
Published: (2020-03-01)

Evolution of Pfdhps and Pfdhfr mutations before and after adopting seasonal malaria chemoprevention in Nanoro, Burkina Faso
by: Francis Emmanuel Towanou Bohissou, et al.
Published: (2024-10-01)

Polymorphism in drug resistance genes dihydrofolate reductase and dihydropteroate synthase in Plasmodium falciparum in some states of India
by: Divya Sharma, et al.
Published: (2015-09-01)

Pfcrt mutant haplotypes may not correspond with chloroquine resistance
by: Diganta Goswami, et al.
Published: (2014-06-01)

Regional variation in sulfadoxine-pyrimethamine resistance genotypes and haplotypes of Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Western Kenya
by: Josephat Bungei, et al.
Published: (2025-10-01)

RETRACTED ARTICLE: Malaria in urban, semi-urban and rural areas of southern of Gabon: comparison of the Pfmdr 1 and Pfcrt genotypes from symptomatic children
by: Sydney Maghendji-Nzondo, et al.
Published: (2016-08-01)

Pfcrt and pfmdr1 alleles associated with chloroquine resistance in Plasmodium falciparum from Guyana, South America
by: Wallis Best Plummer, et al.
Published: (2004-06-01)

Polymorphism of Plasmodium Falciparum Dihydrofolate Reductase and Dihydropteroate Synthase Genes among Pregnant Women with Falciparum Malaria in Banjar District, South Kalimantan Province, Indonesia
by: Sukmawati Basuki, et al.
Published: (2012-12-01)

Prevalence of pfdhfr and pfdhps mutations in Plasmodium falciparum associated with drug resistance among pregnant women receiving IPTp-SP at Msambweni County Referral Hospital, Kwale County, Kenya
by: Stella Wanjiku Gikunju, et al.
Published: (2020-05-01)

Independent Origin of Plasmodium falciparum Antifolate Super-Resistance, Uganda, Tanzania, and Ethiopia
by: Michael Alifrangis, et al.
Published: (2014-08-01)

Clinical isolates of uncomplicated falciparum malaria from high and low malaria transmission areas show distinct pfcrt and pfmdr1 polymorphisms in western Ethiopia
by: Geletta Tadele, et al.
Published: (2023-06-01)

Rebound of multiple infections and prevalence of anti-malarial resistance associated markers following malaria upsurges in Dielmo village, Senegal, West Africa
by: Amélé Nyedzie Wotodjo, et al.
Published: (2023-09-01)

Genetic Profiles of Plasmodium falciparum Isolates from a Therapeutic Efficacy Study on the Antimalarial Drug Dihydroartemisinin-Piperaquine in the West Sumba and Kupang Districts of East Nusa Tenggara Province, Indonesia
by: Irdayanti, et al.
Published: (2025-01-01)

Molecular identification of sulfadoxine-pyrimethamine resistance in malaria infected women who received intermittent preventive treatment in the Democratic Republic of Congo
by: Emrah Ruh, et al.
Published: (2018-01-01)

Unraveling Key Chloroquine Resistance-Associated Alleles Among Plasmodium falciparum Isolates in South Darfur State, Sudan Twelve Years After Drug Withdrawal
by: Magboul AM, et al.
Published: (2024-01-01)

Plasmodium falciparum drug resistance-associated mutations in isolates from children living in endemic areas of Burkina Faso
by: Casimire Wendlamita Tarama, et al.
Published: (2023-07-01)

Different patterns of pfcrt and pfmdr1 polymorphism in Plasmodium falciparum isolates from Tehama region, Yemen
by: Wahib M. Atroosh, et al.
Published: (2016-07-01)

Sequence analysis of coding DNA fragments of pfcrt and pfmdr-1 genes in Plasmodium falciparum isolates from Odisha, India
by: Sasmita Kumari Das Sutar, et al.
Published: (2011-02-01)

Stable high frequencies of sulfadoxine–pyrimethamine resistance associated mutations and absence of K13 mutations in Plasmodium falciparum 3 and 4 years after the introduction of artesunate plus sulfadoxine–pyrimethamine in Ujjain, Madhya Pradesh, India
by: Ashish Pathak, et al.
Published: (2020-08-01)

Distribution patterns of molecular markers of antimalarial drug resistance in Plasmodium falciparum isolates on the Thai-Myanmar border during the periods of 1993–1998 and 2002–2008
by: Phunuch Muhamad, et al.
Published: (2024-03-01)

Plasmodium falciparum transcription factor AP2-06B is mutated at high frequency in Southeast Asia but does not associate with drug resistance
by: Qiyang Shi, et al.
Published: (2025-01-01)

Polymorphisms in K13, pfcrt, pfmdr1, pfdhfr, and pfdhps in parasites isolated from symptomatic malaria patients in Burkina Faso
by: Somé Anyirékun Fabrice, et al.
Published: (2016-01-01)

Molecular markers of anti-malarial drug resistance in Central, West and East African children with severe malaria
by: Christian N. Nguetse, et al.
Published: (2017-05-01)

Genomic characterization of Plasmodium falciparum genes associated with anti-folate drug resistance and treatment outcomes in eastern India: A molecular surveillance study from 2008 to 2017
by: Sabyasachi Das, et al.
Published: (2022-12-01)

Identification of chloroquine resistance Pfcrt-K76T and determination of Pfmdr1-N86Y copy number by SYBR Green I qPCR
by: Addimas Tajebe, et al.
Published: (2015-03-01)

Polymorphism Analysis of <i>pfmdr1</i> and <i>pfcrt</i> from <i>Plasmodium falciparum</i> Isolates in Northwestern Nigeria Revealed the Major Markers Associated with Antimalarial Resistance
by: Ruqayya Adam, et al.
Published: (2021-01-01)

Epidemiology, clinical spectrum, and outcomes of severe malaria in Eastern Uganda: a prospective study
by: Cate Namayanja, et al.
Published: (2025-02-01)

PARIST study protocol: a phase I/II randomised, controlled clinical trial to assess the feasibility, safety and effectiveness of paracetamol in resolving acute kidney injury in children with severe malaria
by: Peter Olupot-Olupot, et al.
Published: (2023-07-01)

Capacity Building in Field Epidemiology in Sub Saharan Africa: Findings from Infectious Disease Field Epidemiology and Biostatistics in Africa (IDEA) Fellowship Program
by: Alunyo JP, et al.
Published: (2025-07-01)