Bacillus thuringiensis Cry14A family proteins as novel anthelmintics against gastrointestinal nematode parasites.

Bacillus thuringiensis crystal (Cry) proteins have been expressed in commercial transgenic crops for nearly 30 years, providing safe and effective control of insect pests and significantly reducing the application of hazardous chemical pesticides. B. thuringiensis crystal proteins have also been sho...

Full description

Bibliographic Details
Published in:	PLoS Neglected Tropical Diseases
Main Authors:	Duy Hoang, Kelly Flanagan, Qian Ding, Nicholas R Cazeault, Hanchen Li, Stefani Díaz-Valerio, Florentina Rus, Esther A Darfour, Elizabeth Kass, Katherine H Petersson, Martin K Nielsen, Heiko Liesegang, Gary R Ostroff, Raffi V Aroian
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2024-10-01
Online Access:	https://doi.org/10.1371/journal.pntd.0012611

Similar Items

An inactivated bacterium (paraprobiotic) expressing Bacillus thuringiensis Cry5B as a therapeutic for Ascaris and Parascaris spp. infections in large animals
by: Joseph F. Urban, Jr, et al.
Published: (2021-06-01)

The nematode (Ascaris suum) intestine is a location of synergistic anthelmintic effects of Cry5B and levamisole.
by: Paul D E Williams, et al.
Published: (2024-05-01)

In vivo and in vitro studies of Cry5B and nicotinic acetylcholine receptor agonist anthelmintics reveal a powerful and unique combination therapy against intestinal nematode parasites.
by: Yan Hu, et al.
Published: (2018-05-01)

Bacillus thuringiensis Cry5B protein as a new pan-hookworm cure
by: Yan Hu, et al.
Published: (2018-08-01)

Anthelmintic Activity of Yeast Particle-Encapsulated Terpenes
by: Zeynep Mirza, et al.
Published: (2020-06-01)

Mechanistic and single-dose in vivo therapeutic studies of Cry5B anthelmintic action against hookworms.
by: Yan Hu, et al.
Published: (2012-01-01)

The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist.
by: Yan Hu, et al.
Published: (2009-08-01)

Variation in anthelmintic responses are driven by genetic differences among diverse C. elegans wild strains.
by: Amanda O Shaver, et al.
Published: (2023-04-01)

Host-Pathogen Coevolution: The Selective Advantage of Bacillus thuringiensis Virulence and Its Cry Toxin Genes.
by: Leila Masri, et al.
Published: (2015-06-01)

Resistance to Cry14A family Bacillus thuringiensis crystal proteins in Caenornabditis elegans operates via the nhr-31 transcription factor and vacuolar-type ATPase pathway.
by: Youmie Kim, et al.
Published: (2024-10-01)

Yeast Particle Encapsulation of Scaffolded Terpene Compounds for Controlled Terpene Release
by: Ernesto R. Soto, et al.
Published: (2021-05-01)

The characterization Molecular of cry genes in the Bacillus thuringiensis isolated from soil
by: R Mahmoudi, et al.
Published: (2017-05-01)

Gastrointestinal nematodes and anthelmintic resistance in Danish goat herds☆
by: Holm Signe A., et al.
Published: (2014-01-01)

Biotransformation of anthelmintics in nematodes in relation to drug resistance
by: Ondřej Vosála, et al.
Published: (2025-04-01)

Discovery of anthelmintic resistant of nematodes of ruminants in region West Kazakhstan
by: R. S. Karmaliev, et al.
Published: (2016-04-01)

Prevalence of anthelmintic resistance of gastrointestinal nematodes in Lithuanian sheep farms
by: Beleckė A., et al.
Published: (2025-05-01)

A highly expressed intestinal cysteine protease of Ancylostoma ceylanicum protects vaccinated hamsters from hookworm infection.
by: Jason B Noon, et al.
Published: (2019-04-01)

Engineering of Bacillus thuringiensis Cry2Ab toxin for improved insecticidal activity
by: Bai-Wen Fu, et al.
Published: (2024-02-01)

Isolation of Iranian Bacillus thuringiensis strains and characterization of lepidopteran-active cry genes
by: Maryam Rashki, et al.
Published: (2021-05-01)

Proteínas Cry de Bacillus thuringiensis y su interacción con coleópteros
by: Silvio Alejandro López-Pazos, et al.
Published: (2010-12-01)

Eﬃcacy of anthelmintic Eprimek against gastrointestinal nematodes in sheep
by: V. I. Kolesnikov
Published: (2020-12-01)

Anthelmintic resistance of horse strongyle nematodes to fenbendazole in Lithuania
by: Evelina Dauparaitė, et al.
Published: (2022-09-01)

Resistance of gastrointestinal nematodes to anthelmintics in sheep (Ovis aries)
by: Vanete Thomaz-Soccol, et al.
Published: (2004-03-01)

Molecular and Kinetic Models for Pore Formation of <i>Bacillus thuringiensis</i> Cry Toxin
by: Haruka Endo
Published: (2022-06-01)

Efficacy of anthelmintics against gastrointestinal nematodes of pigs in Tripura, India
by: ANKAN DE, et al.
Published: (2025-07-01)

On the mechanism of resistance of parasitic nematodes to anthelmintic drugs (brief review)
by: T. A. Malyutina, et al.
Published: (2025-03-01)

First Report of Anthelmintic Resistance in Gastrointestinal Nematodes in Goats in Romania
by: Adrian Valentin Potârniche, et al.
Published: (2021-09-01)

Anthelmintic activity of Sesbania grandiflora against gastrointestinal nematodes of sheep
by: A MEENAKSHISUNDARAM, et al.
Published: (2016-02-01)

Use of an anthelmintic to control parasitic nematodes of Helix aspersa (Müller)
by: N. Shmyhol, et al.
Published: (2021-09-01)

Anthelmintic activity of Indigofera tinctoria against gastrointestinal nematodes of sheep
by: Ambalathaduvar Meenakshisundaram, et al.
Published: (2016-01-01)

First Report of Anthelmintic Resistance in Gastrointestinal Nematodes of Sheep from Costa Rica
by: R. Maroto, et al.
Published: (2011-01-01)

Evaluation of Cytotoxicity, Genotoxicity and Hematotoxicity of the Recombinant Spore-Crystal Complexes Cry1Ia, Cry10Aa and Cry1Ba6 from Bacillus thuringiensis in Swiss Mice
by: Ingrid de Souza Freire, et al.
Published: (2014-09-01)

Identification of similar transcriptional regulatory mechanisms in multiple cry genes in Bacillus thuringiensis HD12
by: Zhi-ru SONG, et al.
Published: (2017-01-01)

Caracterización Molecular de Genes cry de Bacillus thuringiensis Utilizando PCR Extra-Rápida
by: Leonardo Mariño, et al.
Published: (1996-10-01)

Insights from the Structure of an Active Form of <i>Bacillus thuringiensis</i> Cry5B
by: Jiaxin Li, et al.
Published: (2022-11-01)

Transcriptome and Proteome Alternation With Resistance to Bacillus thuringiensis Cry1Ah Toxin in Ostrinia furnacalis
by: Muhammad Zeeshan Shabbir, et al.
Published: (2019-02-01)

Efficacy of anthelmintics against nematodes in naturally infected free range ducks
by: Ausraful Islam, et al.

Mapping resistance-associated anthelmintic interactions in the model nematode Caenorhabditis elegans.
by: Elena G Rehborg, et al.
Published: (2023-10-01)

Anthelmintic-resistant nematodes in Irish commercial sheep flocks- the state of play
by: Good Barbara, et al.
Published: (2012-12-01)

Assessment of the efficacy of commercial anthelmintics in horses naturally infected with gastrointestinal nematodes
by: Natália Soares Martins, et al.
Published: (2021-04-01)