Artemisinin resistance, some facts and opinions

Resistance to artemisinin derivatives (ARTs) in malaria disease is currently defined as a delayed parasite clearance following artemisinin combined therapy (ACT). Although ACT is still widely effective, the first evidence of artemisinin resistance was described in 2009 in Southeast Asia. Since then,...

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Bibliographic Details
Published in:Journal of Infection in Developing Countries
Main Authors: Antonella Pantaleo, Maria Carmina Pau, Huynh Dinh Chien, Francesco Turrini
Format: Article
Language:English
Published: The Journal of Infection in Developing Countries 2015-07-01
Subjects:
artemisinin
delayed clearance of parasites
artemisinin combined therapy
Online Access:https://jidc.org/index.php/journal/article/view/7015
Description
Summary:Resistance to artemisinin derivatives (ARTs) in malaria disease is currently defined as a delayed parasite clearance following artemisinin combined therapy (ACT). Although ACT is still widely effective, the first evidence of artemisinin resistance was described in 2009 in Southeast Asia. Since then, resistance to ARTs / ACT has been monitored showing an increasing trend. The demonstrated resistance to all drugs that are currently associated to ART, the ambiguous finding that ART resistance is observed only in presence of resistance to the partner drug, the lack of a mechanistic rationale to choose the partner drugs and the lack of markers with known specificity and sensitivity to monitor ART resistance, represent the most worrisome issues.
ISSN:1972-2680

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