Upholding or Breaking the Law of Superposition in Pharmacokinetics

The law of superposition underpins first-order linear pharmacokinetic relationships. Most drugs, therefore, after a single dose can be described by first-order or linear processes, which can be superposed to understand multiple-dose regimen behavior. However, there are a number of situations where d...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Malaz Yousef, Jaime A. Yáñez, Raimar Löbenberg, Neal M. Davies
Format:	Article
Language:	English
Published:	MDPI AG 2024-08-01
Subjects:	pharmacokinetics superposition steady state linearity multiple dosing
Online Access:	https://www.mdpi.com/2227-9059/12/8/1843