Exosomes derived from human umbilical cord mesenchymal stem cells reduce tendon injuries via the miR-27b-3p/ARHGAP5/RhoA signaling pathway

Tendon injuries are common clinical issues resulted from tissue overuse and age-related degeneration. Previous sutdies have suggested that exosomes secreted by mesenchymal stem cells (MSCs) contribute to tissue injury repair. Here, we provide evidence for a critical role of human umbilical cord mese...

Full description

Bibliographic Details
Published in:	Acta Biochimica et Biophysica Sinica
Main Authors:	Han Qinghui, Wang Shuguang, Chen Dawei, Gan Di, Wang Tao
Format:	Article
Language:	English
Published:	China Science Publishing & Media Ltd. 2022-01-01
Subjects:	exosomes RhoA ARHGAP5 miR-27b-3p human umbilical cord mesenchymal stem cells
Online Access:	https://www.sciengine.com/doi/10.3724/abbs.2021026

Similar Items

Relationship between the expression of ARHGAP25 and RhoA in non-small cell lung cancer and vasculogenic mimicry
by: Fan Shi, et al.
Published: (2022-10-01)

EHMT2 promotes tumorigenesis in GNAQ/11-mutant uveal melanoma via ARHGAP29-mediated RhoA pathway
by: Yongyun Li, et al.
Published: (2024-03-01)

Influence of ARHGAP29 on the Invasion of Mesenchymal-Transformed Breast Cancer Cells
by: Katharina Kolb, et al.
Published: (2020-12-01)

Effect of alpha-linolenic acid on aminoglycoside nephrotoxicity and RhoA/Rho-kinase pathway in kidney
by: Percin Pazarci, et al.
Published: (2024-10-01)

RhoA/Rho‐kinases in asthma: from pathogenesis to therapeutic targets
by: Yan Zhang, et al.
Published: (2020-01-01)

Pathogenic single nucleotide polymorphisms in RhoA gene: Insights into structural and functional impacts on RhoA-PLD1 interaction through molecular dynamics simulation
by: Mahbub Hasan, et al.
Published: (2024-01-01)

Induced Remodelling of Astrocytes In Vitro and In Vivo by Manipulation of Astrocytic RhoA Activity
by: Cátia Domingos, et al.
Published: (2023-01-01)

Potential role of RhoA GTPase regulation in type interferon signaling in systemic lupus erythematosus
by: Wei Fan, et al.
Published: (2024-01-01)

Alendronate prevents angiotensin II-induced collagen I production through geranylgeranylation-dependent RhoA/Rho kinase activation in cardiac fibroblasts
by: Yang Ye, et al.
Published: (2015-12-01)

RhoA suppresses pseudorabies virus replication in vitro
by: Xin-Man Li, et al.
Published: (2023-11-01)

Depletion of the Rho GTPases Cdc42, Rac1 or RhoA reduces PDGF-induced STAT1 and STAT3 signaling
by: Erik Wåhlén, et al.
Published: (2024-12-01)

Inhibition of RhoA/Rho kinase signaling pathway by fasudil protects against kainic acid‐induced neurite injury
by: Yingchun Xiang, et al.
Published: (2021-08-01)

Nuclear RhoA Activation Regulates Nucleus Size and DNA Content via Nuclear Activation of ROCK and pErk
by: Lap P. Nguyen, et al.
Published: (2025-03-01)

A Novel Single-Color FRET Sensor for Rho-Kinase Reveals Calcium-Dependent Activation of RhoA and ROCK
by: Allison E. Mancini, et al.
Published: (2024-10-01)

RhoA/ROCK2 signaling pathway regulates Mn-induced alterations in tight junction proteins leading to cognitive dysfunction in mice
by: Yan Ma, et al.
Published: (2025-01-01)

Molecular Mechanisms of Alzheimer’s Disease Induced by Amyloid-β and Tau Phosphorylation Along with RhoA Activity: Perspective of RhoA/Rho-Associated Protein Kinase Inhibitors for Neuronal Therapy
by: Eun Hee Ahn, et al.
Published: (2025-01-01)

The role of RhoA in retrograde neuronal death and axon regeneration after spinal cord injury
by: Jianli Hu, et al.
Published: (2017-02-01)

Detection and Quantification of ADP-Ribosylated RhoA/B by Monoclonal Antibody
by: Astrid Rohrbeck, et al.
Published: (2016-04-01)

Melatonin regulates microglial polarization to M2 cell via RhoA/ROCK signaling pathway in epilepsy
by: Pingping Li, et al.
Published: (2023-06-01)

RhoA Signaling in Immune Cell Response and Cardiac Disease
by: Lucia Sophie Kilian, et al.
Published: (2021-07-01)

The mevalonate pathway promotes the metastasis of osteosarcoma by regulating YAP1 activity via RhoA
by: Xing Du, et al.
Published: (2022-05-01)

HIF-1α dependent RhoA as a novel therapeutic target to regulate rheumatoid arthritis fibroblast-like synoviocytes migration in vitro and in vivo
by: Jianhai Chen, et al.
Published: (2023-05-01)

Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-β-catenin signaling axis and static & dynamic dual roles
by: Shidong Shan, et al.
Published: (2023-10-01)

RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling
by: Jirong Wang, et al.
Published: (2023-04-01)

RhoA Drives T-Cell Activation and Encephalitogenic Potential in an Animal Model of Multiple Sclerosis
by: Alba Manresa-Arraut, et al.
Published: (2018-05-01)

RhoA- and Actin-Dependent Functions of Macrophages from the Rodent Cardiac Transplantation Model Perspective -Timing Is the Essence
by: Malgorzata Kloc, et al.
Published: (2021-01-01)

Paeoniflorin inhibits lipopolysaccharide-induced inflammation in LO2 cells by regulating RhoA/NLRP3 pathway
by: Haixia Liu, et al.
Published: (2021-04-01)

RhoA as a Key Regulator of Innate and Adaptive Immunity
by: Matthias Bros, et al.
Published: (2019-07-01)

TAGLN mediated stiffness-regulated ovarian cancer progression via RhoA/ROCK pathway
by: Xiao Wei, et al.
Published: (2021-09-01)

Nesfatin-1 suppresses autophagy of chondrocytes in osteoarthritis via remodeling of cytoskeleton and inhibiting RhoA/ROCK signal pathway
by: Lifeng Jiang, et al.
Published: (2023-03-01)

MicroRNA-141 Inhibits the Proliferation of Penile Cavernous Smooth Muscle Cells Associated with Down-Regulation of the Rhoa/Rho Kinase Signaling Pathway
by: Ying Zhang, et al.
Published: (2018-07-01)

Human lung microvascular endothelial cell protein modification by 2-chlorohexadecanoic acid: RhoA mediates 2-chlorohexadecanoic acid-elicited endothelial activation
by: Haley L. Carlson, et al.
Published: (2025-05-01)

Combined RhoA morpholino and ChABC treatment protects identified lamprey neurons from retrograde apoptosis after spinal cord injury
by: Jianli Hu, et al.
Published: (2023-12-01)

An Anti-Invasive Role for Mdmx through the RhoA GTPase under the Control of the NEDD8 Pathway
by: Lara J. Bou Malhab, et al.
Published: (2024-09-01)

The Protective Effect of Simvastatin on the Systolic Function of the Heart in the Model of Acute Ischemia and Reperfusion Is Due to Inhibition of the RhoA Pathway and Independent of Reduction of MMP-2 Activity
by: Monika Skrzypiec-Spring, et al.
Published: (2022-09-01)

ARHGAP6 Suppresses Breast Cancer Tumor Growth by Promoting Ferroptosis via RhoA-ROCK1-p38 MAPK Signaling
by: Xiaoqing Chen, et al.
Published: (2024-01-01)

Inhibition of RhoA/ROCK signalling pathway activity improves neural damage and cognitive deficits in the fluorosis model
by: Chen Lingli, et al.
Published: (2023-11-01)

RhoA-ROCK Signaling as a Therapeutic Target in Traumatic Brain Injury
by: Shalaka Mulherkar, et al.
Published: (2020-01-01)

Mechanism of SC targeting RhoA regulation and its potential value in gastric cancer therapy
by: Haixiu Ma, et al.
Published: (2025-09-01)

Modified Saengmaeksan, an herbal formula containing six herbs, improves hypertension through RhoA/Rho kinase-mediated vasorelaxation
by: Young Mi Seok, et al.
Published: (2025-12-01)