Multicountry Spread of Influenza A(H1N1)pdm09 Viruses with Reduced Oseltamivir Inhibition, May 2023–February 2024

Since May 2023, a novel combination of neuraminidase mutations, I223V + S247N, has been detected in influenza A(H1N1)pdm09 viruses collected in countries spanning 5 continents, mostly in Europe (67/101). The viruses belong to 2 phylogenetically distinct groups and display ≈13-fold reduced inhibitio...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Emerging Infectious Diseases
المؤلفون الرئيسيون: Mira C. Patel, Ha T. Nguyen, Philippe Noriel Q. Pascua, Rongyuan Gao, John Steel, Rebecca J. Kondor, Larisa V. Gubareva
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Centers for Disease Control and Prevention 2024-07-01
الموضوعات:
Influenza
antiviral
neuraminidase inhibitors
oseltamivir
reduced inhibition
substitution
الوصول للمادة أونلاين:https://wwwnc.cdc.gov/eid/article/30/7/24-0480_article
الوصف
الملخص:Since May 2023, a novel combination of neuraminidase mutations, I223V + S247N, has been detected in influenza A(H1N1)pdm09 viruses collected in countries spanning 5 continents, mostly in Europe (67/101). The viruses belong to 2 phylogenetically distinct groups and display ≈13-fold reduced inhibition by oseltamivir while retaining normal susceptibility to other antiviral drugs.
تدمد:1080-6040
1080-6059

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