| Summary: | <i>Protobothrops mucrosquamatus</i> poses a serious medical threat to humans in Southern and Southeastern Asia. Hemorrhage is one of the conspicuous toxicities related to the pathology of <i>P. mucrosquamatus</i> envenoming. Previous in vitro and in vivo studies showed that a silica-derived reagent, sodium silicate complex (SSC), was able to neutralize hemorrhagic and proteolytic activities induced by pit viper venoms, including <i>Crotalus atrox</i>, <i>Agkistrodon</i><i>contortrix contortrix</i> and <i>Agkistrodon piscivorus leucostoma</i>. In this study, we validated that SSC could neutralize enzymatic and toxic effects caused by the venom of <i>P. mucrosquamatus</i>. We found that SSC inhibited the hemolytic and proteolytic activities induced by <i>P. mucrosquamatus</i> venom in vitro. In addition, we demonstrated that SSC could block intradermal hemorrhage caused by <i>P. mucrosquamatus</i> venom in a mouse model. Finally, SSC could neutralize lethal effects of <i>P. mucrosquamatus</i> venom in the mice. Therefore, SSC is a candidate for further development as a potential onsite first-aid treatment for <i>P. mucrosquamatus</i> envenoming.
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