Albendazole Detection at a Nanomolar Level Through a Fabry–Pérot Interferometer Realized via Molecularly Imprinted Polymers

• 出版年: Sensors
• 主要な著者: Ines Tavoletta, Ricardo Oliveira, Filipa Sequeira, Catarina Cardoso Novo, Luigi Zeni, Giancarla Alberti, Nunzio Cennamo, Rogerio Nunes Nogueira
• フォーマット: 論文
• 言語: 英語
• 出版事項: MDPI AG 2025-10-01
• 主題: Fabry–Pérot interferometer (PFI) probe; molecularly imprinted polymers (MIPs); single-mode fiber (SMF); albendazole (ABZ) detection; optical-chemical sensor
• オンライン･アクセス: https://www.mdpi.com/1424-8220/25/20/6456

Albendazole (ABZ) is a broad-spectrum anthelmintic drug whose residual presence in food and the environment raises public health concerns, requiring rapid and sensitive methods of detection. In this work, a sensitive Fabry–Pérot interferometer (FPI) probe was fabricated by realizing a cavity located at the tip of a single-mode optical fiber core with a molecularly imprinted polymer (MIP) for ABZ detection. The fabrication process involved the development of a photoresist-based micro-hole filled by the specific MIP via thermal polymerization. Interferometric measurements obtained using the proposed sensor system have demonstrated a limit of detection (LOD) of 27 nM, a dynamic concentration range spanning from 27 nM (LOD) to 250 nM, and a linear response at the nanomolar level (27 nM–100 nM). The selectivity test demonstrated no signal when interfering molecules were present, and the application of the sensor for ABZ quantification in a commercial pharmaceutical sample provided good recovery, in accordance with bioanalytical validation standard methods. These results demonstrate the capability of a MIP layer-based FPI probe to provide low-cost and selective optical-sensing strategies, proposing a competitive approach to traditional analytical techniques for ABZ monitoring.