Noncoding RNA in Extracellular Vesicles Regulate Differentiation of Mesenchymal Stem Cells

To achieve the desired outcome in tissue engineering regeneration, mesenchymal stem cells need to undergo a series of biological processes, including differentiating into the ideal target cells. The extracellular vesicle (EV) in the microenvironment contributes toward determining the fate of the cel...

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Bibliographic Details
Published in:Frontiers in Dental Medicine
Main Authors: Chaoting Yan, Jinhua Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Subjects:
noncoding RNA
extracellular vesicles
mesenchymal stem cell
exosome
differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fdmed.2021.806001/full
Description
Summary:To achieve the desired outcome in tissue engineering regeneration, mesenchymal stem cells need to undergo a series of biological processes, including differentiating into the ideal target cells. The extracellular vesicle (EV) in the microenvironment contributes toward determining the fate of the cells with epigenetic regulation, particularly from noncoding RNA (ncRNA), and exerts transportation and protective effects on ncRNAs. We focused on the components and functions of ncRNA (particularly microRNA) in the EVs. The EVs modified by the ncRNA favor tissue regeneration and pose a potential challenge.
ISSN:2673-4915

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