Noncoding RNA in Extracellular Vesicles Regulate Differentiation of Mesenchymal Stem Cells
To achieve the desired outcome in tissue engineering regeneration, mesenchymal stem cells need to undergo a series of biological processes, including differentiating into the ideal target cells. The extracellular vesicle (EV) in the microenvironment contributes toward determining the fate of the cel...
| Published in: | Frontiers in Dental Medicine |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-03-01
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| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fdmed.2021.806001/full |
| _version_ | 1856938375194345472 |
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| author | Chaoting Yan Chaoting Yan Chaoting Yan Jinhua Yu Jinhua Yu |
| author_facet | Chaoting Yan Chaoting Yan Chaoting Yan Jinhua Yu Jinhua Yu |
| author_sort | Chaoting Yan |
| collection | DOAJ |
| container_title | Frontiers in Dental Medicine |
| description | To achieve the desired outcome in tissue engineering regeneration, mesenchymal stem cells need to undergo a series of biological processes, including differentiating into the ideal target cells. The extracellular vesicle (EV) in the microenvironment contributes toward determining the fate of the cells with epigenetic regulation, particularly from noncoding RNA (ncRNA), and exerts transportation and protective effects on ncRNAs. We focused on the components and functions of ncRNA (particularly microRNA) in the EVs. The EVs modified by the ncRNA favor tissue regeneration and pose a potential challenge. |
| format | Article |
| id | doaj-art-9f7a4de4a1ea4e648dbeada3def5cf98 |
| institution | Directory of Open Access Journals |
| issn | 2673-4915 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| spelling | doaj-art-9f7a4de4a1ea4e648dbeada3def5cf982025-08-19T20:11:01ZengFrontiers Media S.A.Frontiers in Dental Medicine2673-49152022-03-01210.3389/fdmed.2021.806001806001Noncoding RNA in Extracellular Vesicles Regulate Differentiation of Mesenchymal Stem CellsChaoting Yan0Chaoting Yan1Chaoting Yan2Jinhua Yu3Jinhua Yu4Key Laboratory of Oral Diseases of Jiangsu Province and Stomatological Institute of Nanjing Medical University, Nanjing, ChinaEndodontic Department, School of Stomatology, Nanjing Medical University, Nanjing, ChinaDepartment of Stomatology, The First People's Hospital of Lianyungang, Lianyungang Clinical Medical College of Nanjing Medical University, Lianyungang, ChinaKey Laboratory of Oral Diseases of Jiangsu Province and Stomatological Institute of Nanjing Medical University, Nanjing, ChinaEndodontic Department, School of Stomatology, Nanjing Medical University, Nanjing, ChinaTo achieve the desired outcome in tissue engineering regeneration, mesenchymal stem cells need to undergo a series of biological processes, including differentiating into the ideal target cells. The extracellular vesicle (EV) in the microenvironment contributes toward determining the fate of the cells with epigenetic regulation, particularly from noncoding RNA (ncRNA), and exerts transportation and protective effects on ncRNAs. We focused on the components and functions of ncRNA (particularly microRNA) in the EVs. The EVs modified by the ncRNA favor tissue regeneration and pose a potential challenge.https://www.frontiersin.org/articles/10.3389/fdmed.2021.806001/fullnoncoding RNAextracellular vesiclesmesenchymal stem cellexosomedifferentiation |
| spellingShingle | Chaoting Yan Chaoting Yan Chaoting Yan Jinhua Yu Jinhua Yu Noncoding RNA in Extracellular Vesicles Regulate Differentiation of Mesenchymal Stem Cells noncoding RNA extracellular vesicles mesenchymal stem cell exosome differentiation |
| title | Noncoding RNA in Extracellular Vesicles Regulate Differentiation of Mesenchymal Stem Cells |
| title_full | Noncoding RNA in Extracellular Vesicles Regulate Differentiation of Mesenchymal Stem Cells |
| title_fullStr | Noncoding RNA in Extracellular Vesicles Regulate Differentiation of Mesenchymal Stem Cells |
| title_full_unstemmed | Noncoding RNA in Extracellular Vesicles Regulate Differentiation of Mesenchymal Stem Cells |
| title_short | Noncoding RNA in Extracellular Vesicles Regulate Differentiation of Mesenchymal Stem Cells |
| title_sort | noncoding rna in extracellular vesicles regulate differentiation of mesenchymal stem cells |
| topic | noncoding RNA extracellular vesicles mesenchymal stem cell exosome differentiation |
| url | https://www.frontiersin.org/articles/10.3389/fdmed.2021.806001/full |
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