Trends in the biological functions and medical applications of extracellular vesicles and analogues
Natural extracellular vesicles (EVs) play important roles in many life processes such as in the intermolecular transfer of substances and genetic information exchanges. Investigating the origins and working mechanisms of natural EVs may provide an understanding of life activities, especially regardi...
| Published in: | Acta Pharmaceutica Sinica B |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-08-01
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| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383521000848 |
| _version_ | 1852768297773170688 |
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| author | Yan Zhao Xiaolu Li Wenbo Zhang Lanlan Yu Yang Wang Zhun Deng Mingwei Liu Shanshan Mo Ruonan Wang Jinming Zhao Shuli Liu Yun Hao Xiangdong Wang Tianjiao Ji Luo Zhang Chenxuan Wang |
| author_facet | Yan Zhao Xiaolu Li Wenbo Zhang Lanlan Yu Yang Wang Zhun Deng Mingwei Liu Shanshan Mo Ruonan Wang Jinming Zhao Shuli Liu Yun Hao Xiangdong Wang Tianjiao Ji Luo Zhang Chenxuan Wang |
| author_sort | Yan Zhao |
| collection | DOAJ |
| container_title | Acta Pharmaceutica Sinica B |
| description | Natural extracellular vesicles (EVs) play important roles in many life processes such as in the intermolecular transfer of substances and genetic information exchanges. Investigating the origins and working mechanisms of natural EVs may provide an understanding of life activities, especially regarding the occurrence and development of diseases. Additionally, due to their vesicular structure, EVs (in small molecules, nucleic acids, proteins, etc.) could act as efficient drug-delivery carriers. Herein, we describe the sources and biological functions of various EVs, summarize the roles of EVs in disease diagnosis and treatment, and review the application of EVs as drug-delivery carriers. We also assess the challenges and perspectives of EVs in biomedical applications. |
| format | Article |
| id | doaj-art-9fc446cbbd714e7db2bbd54b1cc66a08 |
| institution | Directory of Open Access Journals |
| issn | 2211-3835 |
| language | English |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| spelling | doaj-art-9fc446cbbd714e7db2bbd54b1cc66a082025-08-19T20:52:52ZengElsevierActa Pharmaceutica Sinica B2211-38352021-08-011182114213510.1016/j.apsb.2021.03.012Trends in the biological functions and medical applications of extracellular vesicles and analoguesYan Zhao0Xiaolu Li1Wenbo Zhang2Lanlan Yu3Yang Wang4Zhun Deng5Mingwei Liu6Shanshan Mo7Ruonan Wang8Jinming Zhao9Shuli Liu10Yun Hao11Xiangdong Wang12Tianjiao Ji13Luo Zhang14Chenxuan Wang15Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China; State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, ChinaState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, ChinaState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, ChinaState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, ChinaState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, ChinaState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, ChinaState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, ChinaState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, ChinaState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, ChinaDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, ChinaDepartment of Clinical Laboratory, Peking University Civil Aviation School of Clinical Medicine, Beijing 100123, ChinaDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, ChinaDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, ChinaCAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China; Corresponding authors. Tel./fax: +86 10 69156463.Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China; Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China; Corresponding authors. Tel./fax: +86 10 69156463.State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China; Corresponding authors. Tel./fax: +86 10 69156463.Natural extracellular vesicles (EVs) play important roles in many life processes such as in the intermolecular transfer of substances and genetic information exchanges. Investigating the origins and working mechanisms of natural EVs may provide an understanding of life activities, especially regarding the occurrence and development of diseases. Additionally, due to their vesicular structure, EVs (in small molecules, nucleic acids, proteins, etc.) could act as efficient drug-delivery carriers. Herein, we describe the sources and biological functions of various EVs, summarize the roles of EVs in disease diagnosis and treatment, and review the application of EVs as drug-delivery carriers. We also assess the challenges and perspectives of EVs in biomedical applications.http://www.sciencedirect.com/science/article/pii/S2211383521000848Extracellular vesiclesExosomesBiomarkersIntercellular communicationsDrug delivery |
| spellingShingle | Yan Zhao Xiaolu Li Wenbo Zhang Lanlan Yu Yang Wang Zhun Deng Mingwei Liu Shanshan Mo Ruonan Wang Jinming Zhao Shuli Liu Yun Hao Xiangdong Wang Tianjiao Ji Luo Zhang Chenxuan Wang Trends in the biological functions and medical applications of extracellular vesicles and analogues Extracellular vesicles Exosomes Biomarkers Intercellular communications Drug delivery |
| title | Trends in the biological functions and medical applications of extracellular vesicles and analogues |
| title_full | Trends in the biological functions and medical applications of extracellular vesicles and analogues |
| title_fullStr | Trends in the biological functions and medical applications of extracellular vesicles and analogues |
| title_full_unstemmed | Trends in the biological functions and medical applications of extracellular vesicles and analogues |
| title_short | Trends in the biological functions and medical applications of extracellular vesicles and analogues |
| title_sort | trends in the biological functions and medical applications of extracellular vesicles and analogues |
| topic | Extracellular vesicles Exosomes Biomarkers Intercellular communications Drug delivery |
| url | http://www.sciencedirect.com/science/article/pii/S2211383521000848 |
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