Dendritic Cell Subsets in Asthma: Impaired Tolerance or Exaggerated Inflammation?

Asthma is a prevalent chronic heterogeneous inflammatory disease of the airways, leading to reversible airway obstruction, in which various inflammatory responses can be observed. Mild to moderate asthma patients often present with a Th2-mediated eosinophilic inflammation whereas in severe asthma pa...

Full description

Bibliographic Details
Published in:	Frontiers in Immunology
Main Authors:	Heleen Vroman, Rudi W. Hendriks, Mirjam Kool
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-08-01
Subjects:	asthma dendritic cells Th2 cells Th17 cells airway inflammation
Online Access:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00941/full

Similar Items

Targeting ADAM17 to dampen dendritic cell-mediated type 2 immune responses and airway inflammation associated with allergic asthma
by: Anil Kumar Jaiswal, et al.
Published: (2025-08-01)

Bioinformatics analysis of G protein subunit gamma transduction protein 2‐autophagy axis in CD11b+ dendritic cells as a potential regulator to skew airway neutrophilic inflammation in asthma endotypes
by: Xiaoying Ji, et al.
Published: (2024-10-01)

Modulation of lung CD11b+ dendritic cells by acupuncture alleviates Th2 airway inflammation in allergic asthma
by: Mi Cheng, et al.
Published: (2025-05-01)

Pathology of asthma
by: Makoto eKudo, et al.
Published: (2013-09-01)

T-helper cells and their cytokines in pathogenesis and treatment of asthma
by: Tingfen Ji, et al.
Published: (2023-06-01)

Glucan from Dictyophora rubrovolvata boosts immunity by regulating AKT‐STAT1 pathway to induce dendritic cells maturation and T cells differentiation
by: Yu Wu, et al.
Published: (2023-09-01)

Immuno-modulatory activity of <it>Ganoderma lucidum</it>-derived polysacharide on human monocytoid dendritic cells pulsed with Der p 1 allergen
by: Lo Shih-Yen, et al.
Published: (2011-05-01)

Escherichia coli adhesion protein FimH exacerbates colitis via CD11b+CD103- dendritic cell activation
by: Wei Zhang, et al.
Published: (2023-11-01)

Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses
by: Jihyung Lee, et al.
Published: (2020-02-01)

Peripheral blood T helper cell subsets in Löfgren’s and non-Löfgren’s syndrome patients
by: I. V. Kudryavtsev, et al.
Published: (2022-07-01)

The Protective Effects of Astaxanthin on the OVA-Induced Asthma Mice Model
by: Yun-Ho Hwang, et al.
Published: (2017-11-01)

Th17/Treg homeostasis, but not Th1/Th2 homeostasis, is implicated in exacerbation of human bronchial asthma
by: Zou XL, et al.
Published: (2018-09-01)

IL-15 negatively regulates curdlan-induced IL-23 production by human monocyte-derived dendritic cells and subsequent Th17 response
by: Ahmet Eken, et al.
Published: (2019-11-01)

Berberine: A natural modulator of immune cells in multiple sclerosis
by: Esmaeil Yazdanpanah, et al.
Published: (2024-03-01)

Activation of bone marrow-derived dendritic cells and CD4+ T cell differentiation by outer membrane vesicles of periodontal pathogens
by: Younggap Lim, et al.
Published: (2022-12-01)

Plasmodium yoelii 17XL infection modified maturation and function of dendritic cells by skewing Tregs and amplificating Th17
by: Guang Chen, et al.
Published: (2020-04-01)

CpG Oligodeoxynucleotides as a Future Vaccine for Allergic Diseases
by: Kunio Sano, et al.
Published: (2005-01-01)

Cross-talks between natural killer cells and distinct subsets of dendritic cells
by: Guido eFerlazzo, et al.
Published: (2014-04-01)

Content of Th17 related and Th2 cytokines in asthma patients with cold airway hyperresponsiveness
by: A. B. Pirogov, et al.
Published: (2025-03-01)

NECA alleviates inflammatory responses in diabetic retinopathy through dendritic cell toll-like receptor signaling pathway
by: Lanjiao Li, et al.
Published: (2024-06-01)

Th lymphocyte subsets in patients with Vogt-Koyanagi-Harada disease
by: Liang Liang, et al.
Published: (2019-02-01)

FUNCTIONAL PROPERTIES OF IFNΑ-INDUCED DENDRITIC CELLS IN THE PATIENTS WITH PULMONARY TUBERCULOSIS
by: L. V. Sakhno, et al.
Published: (2014-07-01)

Vitamin D3 Priming of Dendritic Cells Shifts Human Neutrophil-Dependent Th17 Cell Development to Regulatory T Cells
by: Florianne M. J. Hafkamp, et al.
Published: (2022-07-01)

T Helper (Th) Cell Profiles in Pregnancy and Recurrent Pregnancy Losses: Th1/Th2/Th9/Th17/Th22/Tfh Cells
by: Wenjuan Wang, et al.
Published: (2020-08-01)

DENDRITIC CELLS AS POSSIBLE REGULATORS OF IMMUNE RE-ORGANIZATION IN PREGNANCY
by: E. R. Chernykh, et al.
Published: (2014-07-01)

Pretreatment Frequency of Circulating Th17 Cells and FeNO Levels Predicted the Real-World Response after 1 Year of Benralizumab Treatment in Patients with Severe Asthma
by: Yuuki Sandhu, et al.
Published: (2023-03-01)

Guominkang formula alleviate inflammation in eosinophilic asthma by regulating immune balance of Th1/2 and Treg/Th17 cells
by: Yumei Zhou, et al.
Published: (2022-10-01)

Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis
by: Neda Haghayegh Jahromi, et al.
Published: (2020-01-01)

FUNCTIONAL ACTIVITY OF IFNα- AND IL-4-INDUCED HUMAN DENDRITIC CELLS: A COMPARATIVE STUDY
by: O. Yu. Leplina, et al.
Published: (2014-07-01)

Migrasomes derived from human umbilical cord mesenchymal stem cells: a new therapeutic agent for ovalbumin-induced asthma in mice
by: Weifeng Gu, et al.
Published: (2025-01-01)

Elevated profiles of peripheral Th22, Th17, Th2 cells, and decreased percentage of Th1 cells in breast cancer patients
by: Zhiguo Peng, et al.
Published: (2023-11-01)

Decrease of IL-5 Production by Naive T Cells Cocultured with IL-18-Producing BCG-Pulsed Dendritic Cells from Patients Allergic to House Dust Mite
by: Magdalena Kowalewicz-Kulbat, et al.
Published: (2021-03-01)

Integration of network pharmacology and experimental validation to explore the pharmacological mechanism of andrographolide against asthma
by: Qian Yu, et al.
Published: (2025-04-01)

Shikonin alleviates asthma phenotypes in mice via an airway epithelial STAT3-dependent mechanism
by: Zhang Yao, et al.
Published: (2024-10-01)

BTLA agonist attenuates Th17-driven inflammation in a mouse model of steroid-resistant asthma
by: Christine Quach, et al.
Published: (2025-03-01)

TLR5 activation in respiratory epithelial cells orchestrate mucosal Th17 response through both indirect and direct pathways
by: Sijian Huang, et al.
Published: (2025-03-01)

Host and microbial factors in regulation of T cells in the intestine
by: Chang H Kim
Published: (2013-06-01)

IL-1β but not programmed death-1 and programmed death-ligand pathway is critical for the human Th17 response to M. tuberculosis
by: Emmanuel Stephen-Victor, et al.
Published: (2016-11-01)

Unbalanced Aryl Hydrocarbon Receptor Expression in Peripheral and Lesional T Cell Subsets of Atopic Dermatitis
by: Hu YQ, et al.
Published: (2023-12-01)

Inmunopatogenia de la psoriasis. Impacto en las manifestaciones clínicas y el tratamiento de la enfermedad Immunopathogenesis of psoriasis. Impact on clinical manifestations and its treatment
by: María Elena Alfonso-Valdés
Published: (2012-12-01)