Novel Diagnostics and Therapeutics in Sepsis

Sepsis management demands early diagnosis and timely treatment that includes source control, antimicrobial therapy, and resuscitation. Currently employed diagnostic tools are ill-equipped to rapidly diagnose sepsis and isolate the offending pathogen, which limits the ability to offer targeted and lo...

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Bibliographic Details
Published in:Biomedicines
Main Authors: Kieran Leong, Bhavita Gaglani, Ashish K. Khanna, Michael T. McCurdy
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Subjects:
sepsis
novel
diagnosis
diagnostics
therapy
therapeutic
Online Access:https://www.mdpi.com/2227-9059/9/3/311
Description
Summary:Sepsis management demands early diagnosis and timely treatment that includes source control, antimicrobial therapy, and resuscitation. Currently employed diagnostic tools are ill-equipped to rapidly diagnose sepsis and isolate the offending pathogen, which limits the ability to offer targeted and lowest-toxicity treatment. Cutting edge diagnostics and therapeutics in development may improve time to diagnosis and address two broad management principles: (1) source control by removing the molecular infectious stimulus of sepsis, and (2) attenuation of the pathological immune response allowing the body to heal. This review addresses novel diagnostics and therapeutics and their role in the management of sepsis.
ISSN:2227-9059

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