Clozapine-induced hypertension: A paradox
Clozapine is a second-generation antipsychotic agent, considered the drug of choice for treatment-resistant schizophrenia. While tachycardia and postural hypotension are common cardiovascular side effects, reports of new-onset persistently elevated blood pressure are rare. We present a case where cl...
| Published in: | Telangana Journal of Psychiatry |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
|
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/tjp.tjp_29_24 |
| Summary: | Clozapine is a second-generation antipsychotic agent, considered the drug of choice for treatment-resistant schizophrenia. While tachycardia and postural hypotension are common cardiovascular side effects, reports of new-onset persistently elevated blood pressure are rare. We present a case where clozapine initiation led to hypertension requiring pharmacological intervention. A 42-year-old female with no prior hypertension and normal baseline blood pressure developed high blood pressure (150/90 mmHg) on clozapine 50 mg/day. These findings were consistent on subsequent trials, necessitating the continuation of amlodipine alongside clozapine at a 100 mg dose to maintain blood pressure control. |
|---|---|
| ISSN: | 2772-8706 2455-8559 |