CCHFV vaccine development, current challenges, limitations, and future directions

Crimean-Congo hemorrhagic fever (CCHF) is the most prevalent tick-borne viral disease affecting humans. The disease is life-threatening in many regions of the developing world, including Africa, Asia, the Middle East, and Southern Europe. In line with the rapidly increasing disease prevalence, vario...

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Bibliographic Details
Published in:Frontiers in Immunology
Main Authors: Büşra Ahata, Günseli Bayram Akçapınar
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Subjects:
Crimean-Congo hemorrhagic fever virus
vaccines
virus-like particle (VLP)
viral vectored vaccines
DNA-based vaccines
mRNA-based vaccines
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1238882/full
Description
Summary:Crimean-Congo hemorrhagic fever (CCHF) is the most prevalent tick-borne viral disease affecting humans. The disease is life-threatening in many regions of the developing world, including Africa, Asia, the Middle East, and Southern Europe. In line with the rapidly increasing disease prevalence, various vaccine strategies are under development. Despite a large number of potential vaccine candidates, there are no approved vaccines as of yet. This paper presents a detailed comparative analysis of current efforts to develop vaccines against CCHFV, limitations associated with current efforts, and future research directions.
ISSN:1664-3224

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