CCHFV vaccine development, current challenges, limitations, and future directions
Crimean-Congo hemorrhagic fever (CCHF) is the most prevalent tick-borne viral disease affecting humans. The disease is life-threatening in many regions of the developing world, including Africa, Asia, the Middle East, and Southern Europe. In line with the rapidly increasing disease prevalence, vario...
| Published in: | Frontiers in Immunology |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-09-01
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| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1238882/full |
| _version_ | 1851858048649265152 |
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| author | Büşra Ahata Büşra Ahata Günseli Bayram Akçapınar |
| author_facet | Büşra Ahata Büşra Ahata Günseli Bayram Akçapınar |
| author_sort | Büşra Ahata |
| collection | DOAJ |
| container_title | Frontiers in Immunology |
| description | Crimean-Congo hemorrhagic fever (CCHF) is the most prevalent tick-borne viral disease affecting humans. The disease is life-threatening in many regions of the developing world, including Africa, Asia, the Middle East, and Southern Europe. In line with the rapidly increasing disease prevalence, various vaccine strategies are under development. Despite a large number of potential vaccine candidates, there are no approved vaccines as of yet. This paper presents a detailed comparative analysis of current efforts to develop vaccines against CCHFV, limitations associated with current efforts, and future research directions. |
| format | Article |
| id | doaj-art-a2bd3dace07049ecb36680dde6f17477 |
| institution | Directory of Open Access Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| spelling | doaj-art-a2bd3dace07049ecb36680dde6f174772025-08-19T22:21:45ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-09-011410.3389/fimmu.2023.12388821238882CCHFV vaccine development, current challenges, limitations, and future directionsBüşra Ahata0Büşra Ahata1Günseli Bayram Akçapınar2Department of Medical Biotechnology, Institute of Health Sciences, Acıbadem Mehmet Ali Aydınlar University, Istanbul, TürkiyeHealth Institutes of Turkey, Istanbul, TürkiyeDepartment of Medical Biotechnology, Institute of Health Sciences, Acıbadem Mehmet Ali Aydınlar University, Istanbul, TürkiyeCrimean-Congo hemorrhagic fever (CCHF) is the most prevalent tick-borne viral disease affecting humans. The disease is life-threatening in many regions of the developing world, including Africa, Asia, the Middle East, and Southern Europe. In line with the rapidly increasing disease prevalence, various vaccine strategies are under development. Despite a large number of potential vaccine candidates, there are no approved vaccines as of yet. This paper presents a detailed comparative analysis of current efforts to develop vaccines against CCHFV, limitations associated with current efforts, and future research directions.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1238882/fullCrimean-Congo hemorrhagic fever virusvaccinesvirus-like particle (VLP)viral vectored vaccinesDNA-based vaccinesmRNA-based vaccines |
| spellingShingle | Büşra Ahata Büşra Ahata Günseli Bayram Akçapınar CCHFV vaccine development, current challenges, limitations, and future directions Crimean-Congo hemorrhagic fever virus vaccines virus-like particle (VLP) viral vectored vaccines DNA-based vaccines mRNA-based vaccines |
| title | CCHFV vaccine development, current challenges, limitations, and future directions |
| title_full | CCHFV vaccine development, current challenges, limitations, and future directions |
| title_fullStr | CCHFV vaccine development, current challenges, limitations, and future directions |
| title_full_unstemmed | CCHFV vaccine development, current challenges, limitations, and future directions |
| title_short | CCHFV vaccine development, current challenges, limitations, and future directions |
| title_sort | cchfv vaccine development current challenges limitations and future directions |
| topic | Crimean-Congo hemorrhagic fever virus vaccines virus-like particle (VLP) viral vectored vaccines DNA-based vaccines mRNA-based vaccines |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1238882/full |
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