Reprogramming resistance: phage-antibiotic synergy targets efflux systems in ESKAPEE pathogens

ABSTRACT Multidrug-resistant (MDR) and extensively drug-resistant (XDR) ESKAPE pathogens pose a significant global health threat due to their ability to evade antibiotics through intrinsic and acquired mechanisms. These bacteria, including Enterococcus faecium, Staphylococcus aureus, Klebsiella pneu...

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Bibliographic Details

Published in:	mBio
Main Authors:	Anita Tarasenko, Bhavya N. Papudeshi, Susanna R. Grigson, Vijini Mallawaarachchi, Abbey L. K. Hutton, Morgyn S. Warner, Jeremy J. Barr, Jon Iredell, Bart Eijkelkamp, Robert A. Edwards
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-10-01
Subjects:	multidrug resistance (MDR) ESKAPEE pathogens phage therapy efflux pump inhibition phage-antibiotic synergy
Online Access:	https://journals.asm.org/doi/10.1128/mbio.01822-25