Molecular mechanisms responsible for SARS-CoV-2 antibody waning and vaccine escape in Omicron sublineages BA.4 and BA.5
Mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome continue to threaten the global landscape of the coronavirus disease 2019 (COVID-19) pandemic. The Omicron variant (B.1.1.529) rapidly displaced previous ‘variants of concern’ (VoC) in 2021 due to its high rate of...
| الحاوية / القاعدة: | Journal of Infection in Developing Countries |
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| المؤلفون الرئيسيون: | , , , , , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
The Journal of Infection in Developing Countries
2022-07-01
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://jidc.org/index.php/journal/article/view/17010 |
| _version_ | 1849674620397944832 |
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| author | Benjamin Hewins Christopher Richardson Salvatore Rubino Alyson Kelvin Ali Toloue Ostadgavahi David J Kelvin |
| author_facet | Benjamin Hewins Christopher Richardson Salvatore Rubino Alyson Kelvin Ali Toloue Ostadgavahi David J Kelvin |
| author_sort | Benjamin Hewins |
| collection | DOAJ |
| container_title | Journal of Infection in Developing Countries |
| description |
Mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome continue to threaten the global landscape of the coronavirus disease 2019 (COVID-19) pandemic. The Omicron variant (B.1.1.529) rapidly displaced previous ‘variants of concern’ (VoC) in 2021 due to its high rate of transmissibility and multitude of mutations. This global influx of infections saturated healthcare systems, overwhelmed testing capacity and case reporting, and increased the COVID-19 death toll. Global health leaders are now being faced with the most transmissible COVID-19 variants yet, the Omicron sublineages BA.4 and BA.5, which contain additional spike protein (S) mutations from previous Omicron and VoC serotypes. With universally observed antibody waning, increasing vaccine-variant mismatch, and resuming international travel, the stage is set for unprecedented levels of breakthrough infections and superspreading events. In this paper, we raise awareness to these novel variants and provide context for the high likelihood of an upcoming wave of infection capable of inflicting significant disease burden on a global scale.
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| format | Article |
| id | doaj-art-a37fc60c3d8546bb86a5d588df7d2293 |
| institution | Directory of Open Access Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| spelling | doaj-art-a37fc60c3d8546bb86a5d588df7d22932025-08-20T02:16:06ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802022-07-01160710.3855/jidc.17010Molecular mechanisms responsible for SARS-CoV-2 antibody waning and vaccine escape in Omicron sublineages BA.4 and BA.5Benjamin Hewins0Christopher Richardson1Salvatore Rubino2Alyson Kelvin3Ali Toloue Ostadgavahi4David J Kelvin5Department of Microbiology and Immunology, Canadian Centre for Vaccinology CCfV, Faculty of Medicine, Dalhousie University, Halifax, CanadaDepartment of Microbiology and Immunology, Canadian Centre for Vaccinology CCfV, Faculty of Medicine, Dalhousie University, Halifax, CanadaDepartment of Biomedical Sciences, University of Sassari, Sassari, ItalyDepartment of Microbiology and Immunology, Canadian Centre for Vaccinology CCfV, Faculty of Medicine, Dalhousie University, Halifax, CanadaDepartment of Microbiology and Immunology, Canadian Centre for Vaccinology CCfV, Faculty of Medicine, Dalhousie University, Halifax, CanadaDepartment of Microbiology and Immunology, Canadian Centre for Vaccinology CCfV, Faculty of Medicine, Dalhousie University, Halifax, Canada Mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome continue to threaten the global landscape of the coronavirus disease 2019 (COVID-19) pandemic. The Omicron variant (B.1.1.529) rapidly displaced previous ‘variants of concern’ (VoC) in 2021 due to its high rate of transmissibility and multitude of mutations. This global influx of infections saturated healthcare systems, overwhelmed testing capacity and case reporting, and increased the COVID-19 death toll. Global health leaders are now being faced with the most transmissible COVID-19 variants yet, the Omicron sublineages BA.4 and BA.5, which contain additional spike protein (S) mutations from previous Omicron and VoC serotypes. With universally observed antibody waning, increasing vaccine-variant mismatch, and resuming international travel, the stage is set for unprecedented levels of breakthrough infections and superspreading events. In this paper, we raise awareness to these novel variants and provide context for the high likelihood of an upcoming wave of infection capable of inflicting significant disease burden on a global scale. https://jidc.org/index.php/journal/article/view/17010Vaccination fatiguevaccine-variant mismatchantibody escapevariants of concern (VoCs)breakthrough infection |
| spellingShingle | Benjamin Hewins Christopher Richardson Salvatore Rubino Alyson Kelvin Ali Toloue Ostadgavahi David J Kelvin Molecular mechanisms responsible for SARS-CoV-2 antibody waning and vaccine escape in Omicron sublineages BA.4 and BA.5 Vaccination fatigue vaccine-variant mismatch antibody escape variants of concern (VoCs) breakthrough infection |
| title | Molecular mechanisms responsible for SARS-CoV-2 antibody waning and vaccine escape in Omicron sublineages BA.4 and BA.5 |
| title_full | Molecular mechanisms responsible for SARS-CoV-2 antibody waning and vaccine escape in Omicron sublineages BA.4 and BA.5 |
| title_fullStr | Molecular mechanisms responsible for SARS-CoV-2 antibody waning and vaccine escape in Omicron sublineages BA.4 and BA.5 |
| title_full_unstemmed | Molecular mechanisms responsible for SARS-CoV-2 antibody waning and vaccine escape in Omicron sublineages BA.4 and BA.5 |
| title_short | Molecular mechanisms responsible for SARS-CoV-2 antibody waning and vaccine escape in Omicron sublineages BA.4 and BA.5 |
| title_sort | molecular mechanisms responsible for sars cov 2 antibody waning and vaccine escape in omicron sublineages ba 4 and ba 5 |
| topic | Vaccination fatigue vaccine-variant mismatch antibody escape variants of concern (VoCs) breakthrough infection |
| url | https://jidc.org/index.php/journal/article/view/17010 |
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