Revealing age-related changes in the intraocular microenvironment and senescence modulators using aqueous humor proteomics and machine learning

BackgroundIn conjunction with age, aqueous humor (AH) proteomics can affect the occurrence and development of age-related eye diseases, which are poorly understood.ObjectiveWe characterized the proteomic changes in AH throughout the aging process to better understand the aging mechanisms of the intr...

Full description

Bibliographic Details
Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Xiaosheng Huang, Tiansheng Chou, Xinhua Liu, Kun Zeng, Liangnan Sun, Zonghui Yan, Shaoyi Mei, Wenqun Xi, Zongyi Zhan, Yi Liu, Songguo Dong, Siqi Liu, Jun Zhao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Subjects:	proteomes aqueous humor aging protein senescence modulator machine learning
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1583330/full

Similar Items

First Evidence Indicates the Physiology- and Axial-Myopia-Dependent Profiles of Steroid Hormones in Aqueous Humor
by: Tiansheng Chou, et al.
Published: (2022-12-01)

The Constitutive Proteome of Human Aqueous Humor and Race Specific Alterations
by: Sai Karthik Kodeboyina, et al.
Published: (2020-11-01)

Fluorophotometric measurements of aqueous-humor flow in Filipino eyes
by: George Emmanuel S.J. Comia, MD, et al.
Published: (2007-12-01)

Higher phosphate concentrations as in aqueous humor of diabetic patients increase intraocular lens calcification
by: Rebecca Buhl, et al.
Published: (2024-08-01)

Insights into myopic choroidal neovascularization based on quantitative proteomics analysis of the aqueous humor
by: Huimin Yu, et al.
Published: (2023-12-01)

Levels of Zinc, Iron, and Copper in the Aqueous Humor of Patients with Primary Glaucoma
by: Yangjiani Li, et al.
Published: (2025-07-01)

Correlation analysis of aqueous humor metabolomics with myopic axial length and choroidal parameters
by: Jiechao Shao, et al.
Published: (2023-08-01)

Retinoblastoma: Aqueous humor liquid biopsy
by: Gisella M. Sanchez, et al.
Published: (2025-01-01)

Tumor DNA sampling from aqueous humor in retinoblastoma – A report from South Asia
by: Rachna Meel, et al.
Published: (2024-03-01)

Aqueous Humor Cytokines in Idiopathic Epiretinal Membrane: Correlation with Disease Severity
by: Tommaso Torresin, et al.
Published: (2024-08-01)

The Effects of Cannabidiol on Aqueous Humor Outflow and Trabecular Meshwork Cell Signaling
by: Alyssa S. Aebersold, et al.
Published: (2022-09-01)

Follow‐up of intraocular retinoblastoma through the quantitative analysis of conserved nuclear DNA sequences in aqueous humor from patients
by: Maria Cuadrado‐Vilanova, et al.
Published: (2023-01-01)

Stage-dependent proteomic alterations in aqueous humor of diabetic retinopathy patients based on data-independent acquisition and parallel reaction monitoring
by: Yeanqi Jin, et al.
Published: (2025-04-01)

Herpesviridae prevalence in aqueous humor using PCR
by: Keorochana N, et al.
Published: (2018-09-01)

Long‐Term Monitoring of ApoE4 within Aqueous Humor Using Intraocular Lenses Containing Target‐Responsive Inverse Opal Hydrogel
by: Hyo Lee, et al.
Published: (2024-12-01)

Unveiling the levels and significance of different serpin family proteins in aqueous humor dynamics
by: Eliza Williams, et al.
Published: (2025-05-01)

Decorin Concentrations in Aqueous Humor of Patients with Diabetic Retinopathy
by: Shermaine W. Y. Low, et al.
Published: (2021-12-01)

Fluorophotometric measurements of aqueous-humor flow in post-YAG laser iridotomy for acute angle closure
by: Karlo D. Jacob, MD, et al.
Published: (2010-12-01)

Exploratory Metabolomic Fingerprinting of Aqueous Humor in Healthy Horses and Donkeys, and in Horses with Ocular Pathologies
by: Ignacio Corradini, et al.
Published: (2025-09-01)

Intraocular nematode and other parasites associated with Physalaemus albonotatus (Anura: Leptodactylidae) from Corrientes, Argentina
by: Cynthya Elizabeth González, et al.
Published: (2019-06-01)

Oxylipins in Aqueous Humor of Primary Open-Angle Glaucoma Patients
by: Jianming Xu, et al.
Published: (2024-09-01)

Evaluation of the relationship between serum and humor aqueous raftlin (Rftn1) levels and diabetic retinopathy
by: Mesen Selma, et al.
Published: (2024-11-01)

Noncontact Optical Measurement of Aqueous Humor Glucose Levels and Correlation with Serum Glucose Levels in Rabbit
by: Yih-Shiou Hwang, et al.
Published: (2021-10-01)

Dynamic Complement Protein Changes in Aqueous Humor and Plasma of Patients With Retinal Vein Occlusion During Ranibizumab Treatment
by: Guo T, et al.
Published: (2025-01-01)

Aqueous Humor Levels of Cytokines and Growth Factors in Patients with Congenital Aniridia
by: A. A. Voskresenskaya, et al.
Published: (2019-12-01)

Stability of ascorbic acid in human aqueous humor
by: Sakae Ito, et al.
Published: (2024-06-01)

Metabolomics Reveals Differences in Aqueous Humor Composition in Patients With and Without Pseudoexfoliation Syndrome
by: Diana Anna Dmuchowska, et al.
Published: (2021-05-01)

Higher Intraocular Levels of Inflammatory Factors are Related to Retinal Vascular and Neurodegeneration in Myopic Retinopathy
by: Zeng L, et al.
Published: (2024-12-01)

Lipid profile in the aqueous humor of diabetic macular edema patients
by: Mengru Su, et al.
Published: (2025-02-01)

Aqueous Humor Cytokines in Non-Proliferative Diabetic Retinopathy
by: Otilia Obadă, et al.
Published: (2022-07-01)

Cytokine Profile in Aqueous Humor of Patients With Ocular Toxocariasis
by: Zhaoxin Jiang, et al.
Published: (2022-05-01)

Aqueous humor proteome of primary open angle glaucoma: A combined dataset of mass spectrometry studies
by: W.H.G Hubens, et al.
Published: (2020-10-01)

Untargeted Metabolomic Study of Patients with Wet Age-Related Macular Degeneration in Aqueous Humor
by: Wei Q, et al.
Published: (2024-09-01)

Expression of microRNAs related to apoptosis in the aqueous humor and lens capsule of patients with glaucoma
by: Hyo Seon Yu, et al.
Published: (2024-02-01)

Differences between Aqueous Humor and Serum Concentrations of BDNF and PPARG Genetic Variants in Glaucoma Patients
by: Tena Križ, et al.
Published: (2025-01-01)

Untargeted Metabolomic Study of Patients with Macular Edema Secondary to Retinal Vein Occlusion in Aqueous Humor
by: Wei Q, et al.
Published: (2025-01-01)

A Multicenter Analysis of Nucleic Acid Quantification Using Aqueous Humor Liquid Biopsy in Retinoblastoma
by: Deborah H. Im, BS, et al.
Published: (2023-09-01)

Increased melatonin levels in aqueous humor of patients with proliferative retinopathy in type 2 diabetes mellitus
by: Erdinc Aydin, et al.
Published: (2016-05-01)

Metabolomic Profiling of Aqueous Humor from Pathological Myopia Patients with Choroidal Neovascularization
by: Qiaoling Wei, et al.
Published: (2023-07-01)

iTRAQ-based proteomics analysis of aqueous humor in patients with dry age-related macular degeneration
by: Si-Chang Qu, et al.
Published: (2019-11-01)