Deep Brain Stimulation and Drug-Resistant Epilepsy: A Review of the Literature

• Published in: Frontiers in Neurology
• Main Authors: Nasser Zangiabadi, Lady Diana Ladino, Farzad Sina, Juan Pablo Orozco-Hernández, Alexandra Carter, José Francisco Téllez-Zenteno
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2019-06-01
• Subjects: anterior thalamic nucleus; electrical stimulation; neuromodulation; neurostimulation; refractory epilepsy; target
• Online Access: https://www.frontiersin.org/article/10.3389/fneur.2019.00601/full

Introduction: Deep brain stimulation is a safe and effective neurointerventional technique for the treatment of movement disorders. Electrical stimulation of subcortical structures may exert a control on seizure generators initiating epileptic activities. The aim of this review is to present the targets of the deep brain stimulation for the treatment of drug-resistant epilepsy.Methods: We performed a structured review of the literature from 1980 to 2018 using Medline and PubMed. Articles assessing the impact of deep brain stimulation on seizure frequency in patients with DRE were selected. Meta-analyses, randomized controlled trials, and observational studies were included.Results: To date, deep brain stimulation of various neural targets has been investigated in animal experiments and humans. This article presents the use of stimulation of the anterior and centromedian nucleus of the thalamus, hippocampus, basal ganglia, cerebellum and hypothalamus. Anterior thalamic stimulation has demonstrated efficacy and there is evidence to recommend it as the target of choice.Conclusion: Deep brain stimulation for seizures may be an option in patients with drug-resistant epilepsy. Anterior thalamic nucleus stimulation could be recommended over other targets.