KLF feedback loops in innate immunity
The Krüppel-like factor (KLF) family of zinc finger transcription factors regulate the expression of genes involved in a wide range of cellular processes, including cell proliferation and differentiation. In haematopoiesis, KLFs have essential roles in myeloid cell differentiation and function. KLF4...
| 發表在: | Frontiers in Immunology |
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| Main Authors: | , , , |
| 格式: | Article |
| 語言: | 英语 |
| 出版: |
Frontiers Media S.A.
2025-06-01
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| 主題: | |
| 在線閱讀: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1606277/full |
| _version_ | 1849568803834298368 |
|---|---|
| author | Jessica M. Salmon Holly Adams Graham W. Magor Andrew C. Perkins |
| author_facet | Jessica M. Salmon Holly Adams Graham W. Magor Andrew C. Perkins |
| author_sort | Jessica M. Salmon |
| collection | DOAJ |
| container_title | Frontiers in Immunology |
| description | The Krüppel-like factor (KLF) family of zinc finger transcription factors regulate the expression of genes involved in a wide range of cellular processes, including cell proliferation and differentiation. In haematopoiesis, KLFs have essential roles in myeloid cell differentiation and function. KLF4 is a critical regulator of macrophage development and initiates pro- and anti-inflammatory signalling pathways in response to various stimuli. KLF2, KLF3 and KLF6 also play important roles in regulating these pathways. Here we review how KLFs cooperate and compete to either activate or repress target genes to influence initiation and resolution of inflammatory responses in macrophages. We also discuss how KLFs may be involved in the development of chronic inflammatory conditions. |
| format | Article |
| id | doaj-art-a7d79e927ea045c4b4e4a2268d7fbe03 |
| institution | Directory of Open Access Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| spelling | doaj-art-a7d79e927ea045c4b4e4a2268d7fbe032025-08-20T02:32:04ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.16062771606277KLF feedback loops in innate immunityJessica M. SalmonHolly AdamsGraham W. MagorAndrew C. PerkinsThe Krüppel-like factor (KLF) family of zinc finger transcription factors regulate the expression of genes involved in a wide range of cellular processes, including cell proliferation and differentiation. In haematopoiesis, KLFs have essential roles in myeloid cell differentiation and function. KLF4 is a critical regulator of macrophage development and initiates pro- and anti-inflammatory signalling pathways in response to various stimuli. KLF2, KLF3 and KLF6 also play important roles in regulating these pathways. Here we review how KLFs cooperate and compete to either activate or repress target genes to influence initiation and resolution of inflammatory responses in macrophages. We also discuss how KLFs may be involved in the development of chronic inflammatory conditions.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1606277/fullmacrophageinflammationKLF4KLF3transcriptional regulationfeedback loops |
| spellingShingle | Jessica M. Salmon Holly Adams Graham W. Magor Andrew C. Perkins KLF feedback loops in innate immunity macrophage inflammation KLF4 KLF3 transcriptional regulation feedback loops |
| title | KLF feedback loops in innate immunity |
| title_full | KLF feedback loops in innate immunity |
| title_fullStr | KLF feedback loops in innate immunity |
| title_full_unstemmed | KLF feedback loops in innate immunity |
| title_short | KLF feedback loops in innate immunity |
| title_sort | klf feedback loops in innate immunity |
| topic | macrophage inflammation KLF4 KLF3 transcriptional regulation feedback loops |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1606277/full |
| work_keys_str_mv | AT jessicamsalmon klffeedbackloopsininnateimmunity AT hollyadams klffeedbackloopsininnateimmunity AT grahamwmagor klffeedbackloopsininnateimmunity AT andrewcperkins klffeedbackloopsininnateimmunity |