The Main Aspects of Infecting Laboratory Animals with Pathogenic Biological Agents of Groups I–II in Accordance with the Requirements of Biological Safety
The use of laboratory animals plays an important role in diagnostic, experimental and production work. Special attention is currently being paid to compliance with the rules of biological safety, which is a crucial aspect when working with laboratory animals infected with pathogenic biological agent...
| Published in: | Проблемы особо опасных инфекций |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | Russian |
| Published: |
Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
2025-10-01
|
| Subjects: | |
| Online Access: | https://journal.microbe.ru/jour/article/view/2206 |
| _version_ | 1848764026479181824 |
|---|---|
| author | E. V. Kislitsina V. G. Germanchuk M. V. Gordeeva T. A. Malyukova E. V. Sazanova |
| author_facet | E. V. Kislitsina V. G. Germanchuk M. V. Gordeeva T. A. Malyukova E. V. Sazanova |
| author_sort | E. V. Kislitsina |
| collection | DOAJ |
| container_title | Проблемы особо опасных инфекций |
| description | The use of laboratory animals plays an important role in diagnostic, experimental and production work. Special attention is currently being paid to compliance with the rules of biological safety, which is a crucial aspect when working with laboratory animals infected with pathogenic biological agents (PBAs) of groups I–II. Every researcher needs to have practical skills when infecting laboratory animals, as well as knowledge of the specifics of each method of infection. The main document regulating the right of legal entities to operate with the agents of particularly dangerous infections in the Russian Federation is SanPiN 3.3686-21 “Sanitary and epidemiological requirements for prevention of infectious diseases”, as well as regulatory and methodological documents and instructions related to safety issues when working with PBA. Sanitary requirements define organizational, sanitary and anti-epidemic (preventive), engineering and technical measures that ensure personal and collective safety and environmental protection. The analysis of the current legislative, regulatory and methodological framework governing the specifics of working with experimental animals infected with PBA will make it possible to take into account all the risks of biological hazard to humans and the environment in a timely manner. An important role is played by the competence of the staff, which is necessary to reduce the biological risks of infecting laboratory animals. |
| format | Article |
| id | doaj-art-a7fcd6eb79014cd1ab7899ff4113a5ce |
| institution | Directory of Open Access Journals |
| issn | 0370-1069 2658-719X |
| language | Russian |
| publishDate | 2025-10-01 |
| publisher | Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” |
| record_format | Article |
| spelling | doaj-art-a7fcd6eb79014cd1ab7899ff4113a5ce2025-10-07T18:45:45ZrusFederal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”Проблемы особо опасных инфекций0370-10692658-719X2025-10-0103495610.21055/0370-1069-2025-3-49-561668The Main Aspects of Infecting Laboratory Animals with Pathogenic Biological Agents of Groups I–II in Accordance with the Requirements of Biological SafetyE. V. Kislitsina0V. G. Germanchuk1M. V. Gordeeva2T. A. Malyukova3E. V. Sazanova4Russian Research Anti-Plague Institute “Microbe”Russian Research Anti-Plague Institute “Microbe”Russian Research Anti-Plague Institute “Microbe”Russian Research Anti-Plague Institute “Microbe”Russian Research Anti-Plague Institute “Microbe”The use of laboratory animals plays an important role in diagnostic, experimental and production work. Special attention is currently being paid to compliance with the rules of biological safety, which is a crucial aspect when working with laboratory animals infected with pathogenic biological agents (PBAs) of groups I–II. Every researcher needs to have practical skills when infecting laboratory animals, as well as knowledge of the specifics of each method of infection. The main document regulating the right of legal entities to operate with the agents of particularly dangerous infections in the Russian Federation is SanPiN 3.3686-21 “Sanitary and epidemiological requirements for prevention of infectious diseases”, as well as regulatory and methodological documents and instructions related to safety issues when working with PBA. Sanitary requirements define organizational, sanitary and anti-epidemic (preventive), engineering and technical measures that ensure personal and collective safety and environmental protection. The analysis of the current legislative, regulatory and methodological framework governing the specifics of working with experimental animals infected with PBA will make it possible to take into account all the risks of biological hazard to humans and the environment in a timely manner. An important role is played by the competence of the staff, which is necessary to reduce the biological risks of infecting laboratory animals.https://journal.microbe.ru/jour/article/view/2206biological safetylaboratory animalspathogenic biological agents of groups i–iimethods of infectionbiological risk |
| spellingShingle | E. V. Kislitsina V. G. Germanchuk M. V. Gordeeva T. A. Malyukova E. V. Sazanova The Main Aspects of Infecting Laboratory Animals with Pathogenic Biological Agents of Groups I–II in Accordance with the Requirements of Biological Safety biological safety laboratory animals pathogenic biological agents of groups i–ii methods of infection biological risk |
| title | The Main Aspects of Infecting Laboratory Animals with Pathogenic Biological Agents of Groups I–II in Accordance with the Requirements of Biological Safety |
| title_full | The Main Aspects of Infecting Laboratory Animals with Pathogenic Biological Agents of Groups I–II in Accordance with the Requirements of Biological Safety |
| title_fullStr | The Main Aspects of Infecting Laboratory Animals with Pathogenic Biological Agents of Groups I–II in Accordance with the Requirements of Biological Safety |
| title_full_unstemmed | The Main Aspects of Infecting Laboratory Animals with Pathogenic Biological Agents of Groups I–II in Accordance with the Requirements of Biological Safety |
| title_short | The Main Aspects of Infecting Laboratory Animals with Pathogenic Biological Agents of Groups I–II in Accordance with the Requirements of Biological Safety |
| title_sort | main aspects of infecting laboratory animals with pathogenic biological agents of groups i ii in accordance with the requirements of biological safety |
| topic | biological safety laboratory animals pathogenic biological agents of groups i–ii methods of infection biological risk |
| url | https://journal.microbe.ru/jour/article/view/2206 |
| work_keys_str_mv | AT evkislitsina themainaspectsofinfectinglaboratoryanimalswithpathogenicbiologicalagentsofgroupsiiiinaccordancewiththerequirementsofbiologicalsafety AT vggermanchuk themainaspectsofinfectinglaboratoryanimalswithpathogenicbiologicalagentsofgroupsiiiinaccordancewiththerequirementsofbiologicalsafety AT mvgordeeva themainaspectsofinfectinglaboratoryanimalswithpathogenicbiologicalagentsofgroupsiiiinaccordancewiththerequirementsofbiologicalsafety AT tamalyukova themainaspectsofinfectinglaboratoryanimalswithpathogenicbiologicalagentsofgroupsiiiinaccordancewiththerequirementsofbiologicalsafety AT evsazanova themainaspectsofinfectinglaboratoryanimalswithpathogenicbiologicalagentsofgroupsiiiinaccordancewiththerequirementsofbiologicalsafety AT evkislitsina mainaspectsofinfectinglaboratoryanimalswithpathogenicbiologicalagentsofgroupsiiiinaccordancewiththerequirementsofbiologicalsafety AT vggermanchuk mainaspectsofinfectinglaboratoryanimalswithpathogenicbiologicalagentsofgroupsiiiinaccordancewiththerequirementsofbiologicalsafety AT mvgordeeva mainaspectsofinfectinglaboratoryanimalswithpathogenicbiologicalagentsofgroupsiiiinaccordancewiththerequirementsofbiologicalsafety AT tamalyukova mainaspectsofinfectinglaboratoryanimalswithpathogenicbiologicalagentsofgroupsiiiinaccordancewiththerequirementsofbiologicalsafety AT evsazanova mainaspectsofinfectinglaboratoryanimalswithpathogenicbiologicalagentsofgroupsiiiinaccordancewiththerequirementsofbiologicalsafety |