Inhibiting CXCR6 promotes senescence of activated hepatic stellate cells with limited proinflammatory SASP to attenuate hepatic fibrosis

This study investigates the previously unexplored role of CXC chemokine receptor 6 (CXCR6) in hepatic fibrosis, where excessive extracellular matrix deposition by activated hepatic stellate cells (aHSCs) drives disease progression. Through analysis of gene expression omnibus datasets and human fibro...

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Bibliographic Details

Published in:	Open Life Sciences
Main Authors:	Sheng Liqin, Wu Yiming, Shen Fei, Xu Chenzhou
Format:	Article
Language:	English
Published:	De Gruyter 2025-08-01
Subjects:	hepatic stellate cells senescence sasp cxcr6 hepatic fibrosis
Online Access:	https://doi.org/10.1515/biol-2025-1151