Optimal dosage protocols for mathematical models of synergy of chemo- and immunotherapy
The release of tumor antigens during traditional cancer treatments such as radio- or chemotherapy leads to a stimulation of the immune response which provides synergistic effects these treatments have when combined with immunotherapies. A low-dimensional mathematical model is formulated which, depen...
| Published in: | Frontiers in Immunology |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-01-01
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| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1303814/full |
| Summary: | The release of tumor antigens during traditional cancer treatments such as radio- or chemotherapy leads to a stimulation of the immune response which provides synergistic effects these treatments have when combined with immunotherapies. A low-dimensional mathematical model is formulated which, depending on the values of its parameters, encompasses the 3 E’s (elimination, equilibrium, escape) of tumor immune system interactions. For the escape situation, optimal control problems are formulated which aim to revert the process to the equilibrium scenario. Some numerical results are included. |
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| ISSN: | 1664-3224 |