Studying the efficacy of low-dose colchicine on clinical outcomes of patients with STEMI: a randomized controlled trial

• Published in: The Egyptian Heart Journal
• Main Authors: Mojtaba Yousefzadeh, Ali Khosrobeigi, Ayoub Salehi
• Format: Article
• Language: English
• Published: SpringerOpen 2024-07-01
• Subjects: Colchicine; STEMI; Inflammation
• Online Access: https://doi.org/10.1186/s43044-024-00515-0

Abstract Background Numerous studies have underscored the essential role of inflammation across all stages of atherosclerosis. While various anti-inflammatory interventions have been implemented to mitigate inflammation-induced injuries, outcomes have been conflicting. Given the essential role of inflammation in these patients and limited data regarding the efficacy of low-dose Colchicine as an anti-inflammatory drug, we aimed to study the efficacy of low-dose Colchicine on clinical outcomes of patients with STEMI in Iran. Results Participants presented with STEMI and qualified revascularization at Shahid Beheshti Hospital in Qom during 2022 and 2023 were included into the study. This study included 172 STEMI patients (114 males and 58 females) within the mean age of 58.93 ± 7.79. Results indicate that colchicine (2 mg for loading dose and 0.5 mg daily for 30 days) and placebo group were not significant differences in identical profiles regarding age and gender. Analyses revealed no significant differences in clinical outcome after the 40-day follow-up period. Conclusions This study revealed that the addition of colchicine did not yield a significant benefit in enhancing the outcomes of patients with STEMI. Clinical trial registration: This study was prospectively registered on Iranian registry of clinical trials, with registration number (IRCT20231001059578N1).