Gastrointestinal Mechanisms Underlying the Cardiovascular Effect of Metformin
Metformin, the most widely prescribed drug therapy for type 2 diabetes, has pleiotropic benefits, in addition to its capacity to lower elevated blood glucose levels, including mitigation of cardiovascular risk. The mechanisms underlying the latter remain unclear. Mechanistic studies have, hitherto,...
| Published in: | Pharmaceuticals |
|---|---|
| Main Authors: | Malcolm J. Borg, Christopher K. Rayner, Karen L. Jones, Michael Horowitz, Cong Xie, Tongzhi Wu |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-11-01
|
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/13/11/410 |
Similar Items
Understanding the action mechanisms of metformin in the gastrointestinal tract
by: Meihui Cheng, et al.
Published: (2024-03-01)
by: Meihui Cheng, et al.
Published: (2024-03-01)
Advances in the mechanism of metformin with wide-ranging effects on regulation of the intestinal microbiota
by: Yue Wang, et al.
Published: (2024-05-01)
by: Yue Wang, et al.
Published: (2024-05-01)
Gut microbiota is correlated with gastrointestinal adverse events of metformin in patients with type 2 diabetes
by: Yuxin Huang, et al.
Published: (2022-11-01)
by: Yuxin Huang, et al.
Published: (2022-11-01)
Effect of metformin and metformin/linagliptin on gut microbiota in patients with prediabetes
by: Yoscelina Estrella Martínez-López, et al.
Published: (2024-04-01)
by: Yoscelina Estrella Martínez-López, et al.
Published: (2024-04-01)
Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions
by: Sayedeh Azimeh Hosseini, et al.
Published: (2026-06-01)
by: Sayedeh Azimeh Hosseini, et al.
Published: (2026-06-01)
Zuojinwan ameliorates depressive-like behavior and gastrointestinal dysfunction in mice by modulating the FXR-bile acid-gut microbiota pathway
by: Dan Qiao, et al.
Published: (2025-06-01)
by: Dan Qiao, et al.
Published: (2025-06-01)
Cardiovascular Effects of Metformin
by: B. T. Kurmanbekova, et al.
Published: (2022-03-01)
by: B. T. Kurmanbekova, et al.
Published: (2022-03-01)
Severity of gastrointestinal side effects of metformin tablet compared to metformin capsule in type 2 diabetes mellitus patients
by: Mansour Siavash, et al.
Published: (2017-01-01)
by: Mansour Siavash, et al.
Published: (2017-01-01)
Effects of metformin on the gut microbiota: A systematic review
by: Pavlo Petakh, et al.
Published: (2023-11-01)
by: Pavlo Petakh, et al.
Published: (2023-11-01)
Chemopreventive Effect of Metformin on Gastric Cancer Development
by: Ka Shing Cheung, et al.
Published: (2022-03-01)
by: Ka Shing Cheung, et al.
Published: (2022-03-01)
Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis
by: Fangyan Wang, et al.
Published: (2024-03-01)
by: Fangyan Wang, et al.
Published: (2024-03-01)
Enteroendocrine Hormone Secretion and Metabolic Control: Importance of the Region of the Gut Stimulation
by: Cong Xie, et al.
Published: (2020-08-01)
by: Cong Xie, et al.
Published: (2020-08-01)
Impact of stool transplantation and metformin on polyp reduction and inflammation in an APC Min mouse model
by: Yeon Ji Kim, et al.
Published: (2025-07-01)
by: Yeon Ji Kim, et al.
Published: (2025-07-01)
Effects of Metformin on the Gut Microbiota in Obesity and Type 2 Diabetes Mellitus
by: Zhang Q, et al.
Published: (2020-12-01)
by: Zhang Q, et al.
Published: (2020-12-01)
Potential benefits of metformin and pioglitazone combination therapy via gut microbiota and metabolites in high-fat diet-fed mice
by: Dongmei Wang, et al.
Published: (2022-10-01)
by: Dongmei Wang, et al.
Published: (2022-10-01)
Cardiovascular effects of metformin: focus on adipose tissue metabolism
by: Olga V. Gruzdeva, et al.
Published: (2022-09-01)
by: Olga V. Gruzdeva, et al.
Published: (2022-09-01)
Metformin Mitigates Sepsis-Related Neuroinflammation via Modulating Gut Microbiota and Metabolites
by: Huayan Zhao, et al.
Published: (2022-04-01)
by: Huayan Zhao, et al.
Published: (2022-04-01)
Effect of Metformin on Antipsychotic-Induced Metabolic Dysfunction: The Potential Role of Gut-Brain Axis
by: Chao Luo, et al.
Published: (2019-04-01)
by: Chao Luo, et al.
Published: (2019-04-01)
Lutein augments the hypoglycemic effect of metformin through the gut microbiota-imidazole propionate axis in type 2 diabetic model mice
by: Kai Liu, et al.
Published: (2025-08-01)
by: Kai Liu, et al.
Published: (2025-08-01)
Are There Differences in Gut Microbiome in Patients with Type 2 Diabetes Treated by Metformin or Metformin and Insulin?
by: Dzięgielewska-Gęsiak S, et al.
Published: (2022-11-01)
by: Dzięgielewska-Gęsiak S, et al.
Published: (2022-11-01)
Unveiling the potential pleiotropic effects of metformin in treating COVID-19: a comprehensive review
by: Pavlo Petakh, et al.
Published: (2023-10-01)
by: Pavlo Petakh, et al.
Published: (2023-10-01)
Combination of Oligofructose and Metformin Alters the Gut Microbiota and Improves Metabolic Profiles, Contributing to the Potentiated Therapeutic Effects on Diet-Induced Obese Animals
by: Qingzhong Li, et al.
Published: (2020-02-01)
by: Qingzhong Li, et al.
Published: (2020-02-01)
The influence of metformin and empagliflozin administration on gut microbiota in individuals with type 2 diabetes mellitus and hypothyroidism
by: K.A. Moskva, et al.
Published: (2024-06-01)
by: K.A. Moskva, et al.
Published: (2024-06-01)
Flos Lonicera Combined with Metformin Ameliorates Hepatosteatosis and Glucose Intolerance in Association with Gut Microbiota Modulation
by: Na R. Shin, et al.
Published: (2017-11-01)
by: Na R. Shin, et al.
Published: (2017-11-01)
Longitudinal variations in the gastrointestinal microbiome of the white shrimp, Litopenaeus vannamei
by: Estefanía Garibay-Valdez, et al.
Published: (2021-08-01)
by: Estefanía Garibay-Valdez, et al.
Published: (2021-08-01)
Metformin Therapy Changes Gut Microbiota Alpha-Diversity in COVID-19 Patients with Type 2 Diabetes: The Role of SARS-CoV-2 Variants and Antibiotic Treatment
by: Pavlo Petakh, et al.
Published: (2023-06-01)
by: Pavlo Petakh, et al.
Published: (2023-06-01)
Microbial succinate promotes the response to metformin by upregulating secretory immunoglobulin a in intestinal immunity
by: Ying Zhang, et al.
Published: (2025-12-01)
by: Ying Zhang, et al.
Published: (2025-12-01)
The emerging role of the microbial-gastrointestinal-neural axis
by: Peter G. McLean, et al.
Published: (2009-10-01)
by: Peter G. McLean, et al.
Published: (2009-10-01)
Metformin-associated gut microbiota remodeling correlates with reinvigorated splenic immunity in aged mice: microbiome-immune crosstalk via the gut-spleen axis
by: Shu-Qin Ding, et al.
Published: (2025-09-01)
by: Shu-Qin Ding, et al.
Published: (2025-09-01)
Risk of antidepressant initiation among users of cardiovascular agents and metformin.
by: Ivana Bojanić, et al.
Published: (2023-04-01)
by: Ivana Bojanić, et al.
Published: (2023-04-01)
Editorial: The role of gut microbiota in animal gastrointestinal diseases
by: Aoyun Li, et al.
Published: (2025-01-01)
by: Aoyun Li, et al.
Published: (2025-01-01)
Pathogenic role of the gut microbiota in gastrointestinal diseases
by: Hiroko Nagao-Kitamoto, et al.
Published: (2016-04-01)
by: Hiroko Nagao-Kitamoto, et al.
Published: (2016-04-01)
Gut microbiota-derived glutathione from metformin treatment alleviates intestinal ferroptosis induced by ischemia/reperfusion
by: Fangyan Wang, et al.
Published: (2025-05-01)
by: Fangyan Wang, et al.
Published: (2025-05-01)
Metformin-Associated Gastrointestinal Adverse Events Are Reduced by Probiotics: A Meta-Analysis
by: Izabela Szymczak-Pajor, et al.
Published: (2024-07-01)
by: Izabela Szymczak-Pajor, et al.
Published: (2024-07-01)
The effects of prebiotics on gastrointestinal side effects of metformin in youth: A pilot randomized control trial in youth-onset type 2 diabetes
by: Sydney A. Dixon, et al.
Published: (2023-02-01)
by: Sydney A. Dixon, et al.
Published: (2023-02-01)
Naringenin Promotes Gastrointestinal Motility in Mice by Impacting the SCF/c-Kit Pathway and Gut Microbiota
by: Lei Wu, et al.
Published: (2024-08-01)
by: Lei Wu, et al.
Published: (2024-08-01)
Sex differences in the skeletal muscle response to metformin treatment and the possible association with gut-muscle axis in rats
by: Lin Song, et al.
Published: (2025-09-01)
by: Lin Song, et al.
Published: (2025-09-01)
Is there a relationship between metformin-related gastrointestinal symptoms and vitamin B12 deficiency in patients with type 2 diabetes mellitus?
by: Fatih Eskin, et al.
Published: (2023-03-01)
by: Fatih Eskin, et al.
Published: (2023-03-01)
Metformin beyond Glycemic Control: New Mechanistic Insights and Expanding Therapeutic Horizons
by: Eugene Han, et al.
Published: (2026-05-01)
by: Eugene Han, et al.
Published: (2026-05-01)
Effects of isolation and confinement on gastrointestinal microbiota–a systematic review
by: Bea Klos, et al.
Published: (2023-07-01)
by: Bea Klos, et al.
Published: (2023-07-01)
Similar Items
-
Understanding the action mechanisms of metformin in the gastrointestinal tract
by: Meihui Cheng, et al.
Published: (2024-03-01) -
Advances in the mechanism of metformin with wide-ranging effects on regulation of the intestinal microbiota
by: Yue Wang, et al.
Published: (2024-05-01) -
Gut microbiota is correlated with gastrointestinal adverse events of metformin in patients with type 2 diabetes
by: Yuxin Huang, et al.
Published: (2022-11-01) -
Effect of metformin and metformin/linagliptin on gut microbiota in patients with prediabetes
by: Yoscelina Estrella Martínez-López, et al.
Published: (2024-04-01) -
Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions
by: Sayedeh Azimeh Hosseini, et al.
Published: (2026-06-01)
